The psoriasis model induced by the chronic application of imiquimod (IMI) proposed by ETAP-Lab reproducibly replicates the key markers of the pathology observed in humans: hyperproliferation of keratinocytes, hyperkeratosis and parakeratosis. At the systemic level, the strong activation of the immune system alongside the increased expression of characteristic cytokines such as IL-6, Il-17, IL-23 and TNF-alpha is also consistent with human pathology. Psoriasis is not, however, limited to these parameters classically measured in animals. Indeed, the skin discomfort induced by

Evidence from various studies indicates that Alzheimer's Disease (AD) develops as a result of interaction between multiple complex and overlapping pathophysiological pathways, suggesting that a pharmacological treatment with a combinatorial approach may be more beneficial than monotherapy. AD currently represents the most common form of dementia in elderly people, and with rising life expectancy the number of patients suffering from AD is expected to increase over the coming years, reaching 132 million by 2050 (World Alzheimer Report). The causes of AD are

On the basis of the amyloid hypothesis of Alzheimer’s Disease (AD), most of the clinical trials conducted have concerned Aβ clearing therapy. Because of multiple failures in anti-amyloid clinical drug trials, more attention has been drawn to therapies targeted at tau in AD drug development. Disease-modifying therapies for AD and other tauopathies are targeting post-translational modifications, tau aggregation, microtubule stabilization, regulation of tau expression and tau clearance (immunotherapies). currently lists about 120 studies targeting tau as a treatment for

As its name suggests, the microtubule-associated protein tau is known mainly for its role in stabilising the microtubules, thus contributing to maintenance of the axonal transport mechanisms essential to the survival of neurons. However, the physiological roles of tau are not limited to this function alone; tau is also involved in synaptic plasticity as well as in the regulation and protection of the genome . As we shall discuss in this article, changes in the functions of tau work together

One common pathological hallmark of neurodegenerative disease (ND) is the aggregation and accumulation of misfolding proteins, resulting in neuronal dysfunction and brain damage. A growing body of literature suggests that amyloid oligomers (including tau) are the root cause of ND.  Significant investment has been made in drug development. However, no curative molecule is currently available on the market. This may be due to several factors - most notably to flawed preclinical research in which the use and outcome of animals

In January 2018, we announced the validation of a new model of atopic dermatitis in mice.  Now that we have 18 months' experience of using it, here's our feedback. Back in January 2018, we announced the validation of a new model of atopic dermatitis in mice using topical applications of 2,4-Dinitrochlorobenzene (DNCB) over a period of 5 weeks in Balb/c mice (Newsletter #1). This validation allowed us to show that the model reproduces the essential characteristics of human pathology, and in

The ETAP-Cell project continues to make progress as per the expected timeline. The whole team is delighted to announce that the in vitro laboratory is now fully equipped and already producing its first results! In late January, ETAP-Lab created ETAP-Cell, a new in vitro pharmacological service in the field of evaluating proteopathic neurodegenerative diseases using our unique know-how in the solubilization and stabilization of oligomeric proteins (AβO, αSO and TauO). Three weeks ago, we successfully produced our first batch of soluble Aβ

  Within the framework of the European project MEDILIGHT, the consortium selected ETAP-Lab to outsource a preclinical study aiming at evaluating the efficacy of a miniaturized smart system built up to improve wound healing by light stimulation Chronic wounds represent a significant burden to patients, healthcare professionals, and healthcare systems, affecting over 40 million patients and creating costs of approximately € 40 billion annually. The European project MEDILIGHT aims to develop a smart, wearable medical device that utilizes the

New ETAP-Lab studies on TEMISIS’ drug candidate TEM1657 for Psoriasis ETAP-Lab performed new studies for the account of TEMISIS on a mouse imiquimod-induced psoriasis model. The output of these studies showed that TEM1657 brings remarkable effects on psoriasis: • Higher efficacy compared to the reference molecule • No side effects • Oral administration, which is new for the psoriasis treatment The French biotech company “Temesis”, subsidiary of Plant Advanced Technologies, recently published a new press release to announce these new promising preclinical results on psoriasis

ETAP-Lab supports Plant Advanced Technologies in the development of its TEM1657 compound for the treatment of psoriasis TEM1657 is a drug candidate discovered and optimized by Plant Advanced Technologies (PAT), a French Biotech company based in Vandœuvre-lès-Nancy. The preclinical studies perfomed with TEM1657 in Etap-Lab's model of psoriasis in mice have demonstrated a similar efficacy to that of corticosteroids, the current reference of the market, but without their undesirable side effects. The results have been presented for the first time at the BIO convention in San Diego (USA)