Inflammation adversely affects the health of millions of people worldwide, and there is an unmet medical need for better anti-inflammatory drugs. We evaluated the therapeutic interest of mycolactone, a polyketide-derived macrolide produced by Mycobacterium ulcerans. Bacterial production ofmycolactone in human skin causes a combination of ulcerative, analgesic, and anti-inflammatory effects. Whereas ulcer formation is mediated by the proapoptotic activity of mycolactone on skin cells via hyperactivation of Wiskott-Aldrich syndrome proteins, analgesia results from neuronal hyperpolarization via signaling through angiotensin II type 2 receptors. Mycolactone also blunts the capacity of immune

En Europe, l’incidence des plaies est estimée à quatre millions de cas. Les conséquences associées représentent une problématique clinique importante. Réduire le temps de cicatrisation présenterait un grand intérêt et le statut nutritionnel des individus pourrait y jouer un rôle. La chlorelle verte, une microalgue traditionnellement consommée au Japon, aurait, selon plusieurs études in vivo, un effet positif sur le délai de guérison des plaies. L’objectif de cette étude était d’évaluer l’effet de la chlorelle verte ROQUETTE Chlorella sp., administrée par voie orale, sur

Methyl donor deficiencies and chronic stress cause depression independently, but their interaction has never been thoroughly evaluated. In our study, methyl donor deficient diet and chronic stress condition consisted respectively of a B2, B9, B12, and choline-free diet and a chronic mild stress procedure. Rats were randomly assigned to six groups with three "diet" conditions (free-feeding, pair-fed and methyl donor deficient diet) and two "stress" conditions (no-stress and stress) and were evaluated in the open-field, the elevated plus-maze and the

The orange-peel derived terpene d-Limonene, probably through its metabolite, perillyl alcohol (POH), has been reported to have tissue-repair properties. Two murine models of respectively 12-O-Tetradecanoylphorbol-13-Acetate (TPA)-induced dermatitis and mechanical skin lesion were used here to assess the efficacy of d-Limonene or POH applied topically. Macroscopic and microscopic evaluation of skin lesions was performed as well as that of P-selectin expression, together with measurements of serum concentrations of IL-1β, IL-6 and TNF-αin the first model. Healing and angiogenesis around the scar

University Paris Sud 11, Cell Biology, Biopark CAmpus CAncer, Villejuif, France, 94807, AISA Therapeutics, Genopole, 4, rue Pierre Fontaine, EVRY, France, 91058 ; Stress is closely linked by its biological mechanisms to inflammation and by its consequences to accelerated aging. Stress triggers a hormonal response along the hypothalamus-pituitary-adrenal (HPA) axis, liable to disrupt the ortho / parasympathetic balance essential for a harmonious life. Proper nutrition and adequate physical activity, by limiting the harmful influence of stress, play important roles to avoid

AgroParisTech, UMR 0791 Modélisation Systémique Appliquée aux Ruminants, F-75005 Paris, France; INRA, UMR 0791 Modélisation Systémique Appliquée aux Ruminants, 16 rue Claude Bernard, F-75005 Paris, France. Electronic address: Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse. C57BL/6J mice orally exposed to 9% H. radicata (HR) are metabolically competent laboratory animals which can be used as model of Australian stringhalt, a neurological horse disease induced by HR ingestion. So, the

The TLC-Ag dressings, a combination of technology lipido-colloid and silver salts, are used to promote healing in wounds with risks or signs of local infection, thanks to the antimicrobial properties of the silver salts. Nanocrystalline silver dressings containing nanocrystalline silver, also used to improve wound healing, present both antimicrobial and anti-inflammatory effects. The aim of this study was to investigate the anti-inflammatory effects of TLC-Ag dressings in a model of chronic skin inflammation induced by repeated application of 12-O-tetradecanoylphorbol-13-acetate to

BIO SERAE Laboratoires S.A.S., 129 chemin de Croisset. BP 4151, 76723, Rouen, cedex 3, France. Seaweed extract of Ascophyllum nodosum, ID-alG™, was evaluated for its chronic effects on weight management in high-fat-fed Sprague-Dawley rats. ID-alG™ was orally administered daily during 9 weeks at doses of 40 and 400 mg/kg/day with fat-enriched diet (FED) in comparison with two control groups consuming standard diet (negative control) or FED (positive control) and orally treated with vehicle. Body weight, percentage of body fat mass and