{"id":3286,"date":"2026-01-22T17:20:37","date_gmt":"2026-01-22T16:20:37","guid":{"rendered":"https:\/\/www.etap-lab.com\/cro-services\/neurovascular-stroke\/in-vitro-models\/"},"modified":"2026-04-28T09:31:42","modified_gmt":"2026-04-28T07:31:42","slug":"in-vitro-models","status":"publish","type":"page","link":"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vitro-models\/","title":{"rendered":"In vitro models"},"content":{"rendered":"\r\n<section id=\"header-modeles-block_85922c7f350034b33edc1758689ccf4f\" class=\"header-modeles alignfull\">\r\n  <div class=\"header-modeles__inner\">\r\n\r\n    <div class=\"header-modeles__container\">\r\n\r\n      <div class=\"header-modeles__top\">\r\n                  <div class=\"header-modeles__title\">\r\n            <img decoding=\"async\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/02\/etap-lab-strok@lliance-full-color-rgb-900px-w-72ppi.png\" alt=\"Neurovascular &amp; Stroke\" \/>\r\n          <\/div>\r\n        \r\n                  <a class=\"header-modeles__back\" href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/\">\r\n            <span class=\"header-modeles__back-arrow\" aria-hidden=\"true\">\u2190<\/span>\r\n            <span class=\"header-modeles__back-label\">Neurovascular &amp; Stroke<\/span>\r\n          <\/a>\r\n              <\/div>\r\n\r\n      <div class=\"header-modeles__bottom\">\r\n\r\n        <div class=\"header-modeles__tabs\" role=\"tablist\" aria-label=\"Navigation mod\u00e8les\">\r\n\r\n                      <a\r\n              class=\"header-modeles__tab is-active\"\r\n              href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vitro-models\/\"\r\n              role=\"tab\"\r\n              aria-selected=\"true\"\r\n            >\r\n              In vitro models            <\/a>\r\n          \r\n                      <a\r\n              class=\"header-modeles__tab \"\r\n              href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vivo-models\/\"\r\n              role=\"tab\"\r\n              aria-selected=\"false\"\r\n            >\r\n              In vivo models            <\/a>\r\n          \r\n        <\/div>\r\n\r\n        <div class=\"header-modeles__breadcrumb\">\r\n          <nav class=\"breadcrumb\" aria-label=\"Fil d&#039;Ariane\"><span><span><a href=\"https:\/\/www.etap-lab.com\/en\/\">Home<\/a><\/span><\/span><\/nav>        <\/div>\r\n\r\n      <\/div>\r\n\r\n    <\/div>\r\n  <\/div>\r\n<\/section>\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-6ea5bcae wp-block-columns-is-layout-flex\" style=\"margin-top:0;margin-bottom:0;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\r\n<nav id=\"menu-modeles-block_0a8c72275a80141a800c5ad4f70732e4\" class=\"menu-modeles\" aria-label=\"Menu mod\u00e8les\">\r\n\r\n  <div class=\"menu-modeles__inner\">\r\n\r\n    <div class=\"menu-modeles__head\">\r\n      <h2 class=\"menu-modeles__title\">\r\n        <span class=\"menu-modeles__title-prefix\">Pharmacology<\/span>\r\n        <span class=\"menu-modeles__title-suffix\"><em class=\"menu-modeles__title-em\">In vitro<\/em> models<\/span>\r\n      <\/h2>\r\n    <\/div>\r\n\r\n    <div class=\"menu-modeles__body\">\r\n\r\n              <div class=\"menu-modeles__groups\">\r\n\r\n          \r\n            <details class=\"menu-modeles__group\">\r\n              <summary class=\"menu-modeles__group-summary\">\r\n                <span class=\"menu-modeles__group-arrow\" aria-hidden=\"true\">\u2191<\/span>\r\n                <span class=\"menu-modeles__group-title\">Fibrinolysis and hemostasis screening<\/span>\r\n              <\/summary>\r\n\r\n              <div class=\"menu-modeles__group-panel\">\r\n                <div class=\"menu-modeles__group-panel-inner\">\r\n                  <ul class=\"menu-modeles__items\">\r\n\r\n                                                                <li class=\"menu-modeles__item\">\r\n                        <a class=\"menu-modeles__link\" href=\"#cat-179\">\r\n                          <span class=\"menu-modeles__link-label\">Fibrinolysis and hemostasis screening<\/span>\r\n                          <span class=\"menu-modeles__link-arrow\" aria-hidden=\"true\">\u2192<\/span>\r\n                        <\/a>\r\n                      <\/li>\r\n\r\n                    \r\n                  <\/ul>\r\n                <\/div>\r\n              <\/div>\r\n            <\/details>\r\n\r\n          \r\n            <details class=\"menu-modeles__group\">\r\n              <summary class=\"menu-modeles__group-summary\">\r\n                <span class=\"menu-modeles__group-arrow\" aria-hidden=\"true\">\u2191<\/span>\r\n                <span class=\"menu-modeles__group-title\">Neuroprotective screening<\/span>\r\n              <\/summary>\r\n\r\n              <div class=\"menu-modeles__group-panel\">\r\n                <div class=\"menu-modeles__group-panel-inner\">\r\n                  <ul class=\"menu-modeles__items\">\r\n\r\n                                                                <li class=\"menu-modeles__item\">\r\n                        <a class=\"menu-modeles__link\" href=\"#cat-181\">\r\n                          <span class=\"menu-modeles__link-label\">Neuroprotective screening<\/span>\r\n                          <span class=\"menu-modeles__link-arrow\" aria-hidden=\"true\">\u2192<\/span>\r\n                        <\/a>\r\n                      <\/li>\r\n\r\n                    \r\n                  <\/ul>\r\n                <\/div>\r\n              <\/div>\r\n            <\/details>\r\n\r\n          \r\n            <details class=\"menu-modeles__group\">\r\n              <summary class=\"menu-modeles__group-summary\">\r\n                <span class=\"menu-modeles__group-arrow\" aria-hidden=\"true\">\u2191<\/span>\r\n                <span class=\"menu-modeles__group-title\">Pharmacological interaction and hemostasis<\/span>\r\n              <\/summary>\r\n\r\n              <div class=\"menu-modeles__group-panel\">\r\n                <div class=\"menu-modeles__group-panel-inner\">\r\n                  <ul class=\"menu-modeles__items\">\r\n\r\n                                                                <li class=\"menu-modeles__item\">\r\n                        <a class=\"menu-modeles__link\" href=\"#cat-180\">\r\n                          <span class=\"menu-modeles__link-label\">Pharmacological interaction and hemostasis<\/span>\r\n                          <span class=\"menu-modeles__link-arrow\" aria-hidden=\"true\">\u2192<\/span>\r\n                        <\/a>\r\n                      <\/li>\r\n\r\n                    \r\n                  <\/ul>\r\n                <\/div>\r\n              <\/div>\r\n            <\/details>\r\n\r\n          \r\n        <\/div>\r\n      \r\n      <div class=\"menu-modeles__footer\">\r\n        <a class=\"menu-modeles__plateformes\" href=\"#nos-plateformes\">\r\n          Our platforms        <\/a>\r\n      <\/div>\r\n\r\n    <\/div>\r\n\r\n  <\/div>\r\n<\/nav><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h1 class=\"wp-block-heading\" style=\"padding-top:0;padding-bottom:0\"><em>in vitro<\/em> pharmacology models in Neurovascular &amp; Stroke<\/h1>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1280\" height=\"250\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/stk-vitro.jpg\" alt=\"\" class=\"wp-image-2779\" style=\"object-fit:cover\" srcset=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/stk-vitro.jpg 1280w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/stk-vitro-300x59.jpg 300w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/stk-vitro-1024x200.jpg 1024w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/stk-vitro-768x150.jpg 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/figure>\n\n\n\n<p class=\"has-l-font-size\">With <strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-blue-light-color\">STROK@LLIANCE<\/mark><\/strong>, accelerate the development of your ischemic and hemorrhagic stroke therapies with our preclinical <em>in vitro<\/em> models based on primary neuronal cultures and human blood-based assays. We support you in:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li class=\"has-m-font-size\">Assessing the efficacy and dose-response profiles of your drug benchmarked against relevant reference compound<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li class=\"has-m-font-size\">Screening and identifying neuroprotective, thrombolytic, anticoagulant, hemostatic, and antidote candidates targeting bleeding events associated with hemostasis-modulating therapies <\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li class=\"has-m-font-size\">Characterizing mechanisms of action using human whole blood, plasma, or serum for hemostasis-related investigations, or primary neuronal cultures, hIPSC-derived systems, or organ-on-chip platforms for neuroprotection studies<\/li>\n\n\n\n<li class=\"has-m-font-size\">Investigating drug-drug interactions between your candidate and current standard-of-care treatments used in clinical practice, for potentiation assessments or non-regulatory safety evaluations. <\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-primary\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.etap-lab.com\/en\/contact\/\">Contact an expert<\/a><\/div>\n\n\n\n<div class=\"wp-block-button is-style-secondary\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vivo-models\/\"><strong>Discover our <em>in vivo<\/em> models<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:var(--wp--preset--spacing--70);margin-bottom:0\">\r\n<section id=\"liste-modeles-block_5b440d45aed0627d313bd8fbd8031c68\" class=\"liste-modeles\">\r\n  <div class=\"liste-modeles__inner\">\r\n\r\n    \r\n      \r\n        <article class=\"liste-modeles__section\">\r\n\r\n          <div class=\"liste-modeles__section-head\">\r\n            <div class=\"liste-modeles__section-headtop\">\r\n                              <div class=\"liste-modeles__section-badge\" aria-hidden=\"true\">\r\n                  <img decoding=\"async\" class=\"liste-modeles__section-badge-img\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/syn-vitro-1024x200.jpg\" alt=\"in vitro orange cardiology\">\r\n                <\/div>\r\n              \r\n              <h2 id=\"cat-179\" class=\"liste-modeles__section-title\">\r\n                Fibrinolysis and hemostasis screening              <\/h2>\r\n            <\/div>\r\n\r\n                      <\/div>\r\n\r\n          <div class=\"liste-modeles__section-body\">\r\n\r\n            \r\n              \r\n              <div class=\"liste-modeles__accordions\">\r\n                \r\n                  <details class=\"liste-modeles__acc has-media \"\r\n                           >\r\n                    <summary class=\"liste-modeles__acc-summary\" >\r\n                      <span class=\"liste-modeles__acc-arrow\" aria-hidden=\"true\">\u2193<\/span>\r\n                      <span class=\"liste-modeles__acc-title\">Clot lysis assay<\/span>\r\n                    <\/summary>\r\n\r\n                                          <div class=\"liste-modeles__acc-panel\">\r\n                        <div class=\"liste-modeles__acc-panel-inner\">\r\n                          <div class=\"liste-modeles__acc-grid \">\r\n\r\n                            <div class=\"liste-modeles__acc-content\">\r\n                              <div class=\"liste-modeles__acc-text\">\r\n                                \n<p>The clot lysis assay evaluates the efficacy of your fibrinolytic candidates on human plasma pools. Performed by turbidimetry in 96-well plates, it provides rapid assessment of compounds activity through parameters such as the 50% clot lysis time (LT50). The high reproducibility of the assay ensures reliable and straightforward comparison of dose-response curves throughout lead-optimisation phases.   <\/p>\n\n<p>This assay also allows investigation of compound interactions when combined with reference fibrinolytics (Alteplase, Tenecteplase).<\/p>\n\n<p><\/p>\n                              <\/div>\r\n\r\n                              \r\n                                                              <div class=\"liste-modeles__btnwrap\">\r\n                                  <a class=\"btn_secondary\" href=\"https:\/\/www.etap-lab.com\/en\/contact\/\">\r\n                                    Get the data sheet                                  <\/a>\r\n                                <\/div>\r\n                                                          <\/div>\r\n\r\n                                                          <div class=\"liste-modeles__acc-media\" aria-hidden=\"true\">\r\n                                <img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-clotlysis-1024x683.jpg\" class=\"liste-modeles__acc-img wp-post-image\" alt=\"invitro-clotlysis assay in a lab blue\" srcset=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-clotlysis-1024x683.jpg 1024w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-clotlysis-300x200.jpg 300w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-clotlysis-768x512.jpg 768w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-clotlysis-1536x1024.jpg 1536w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-clotlysis.jpg 1800w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>                              <\/div>\r\n                            \r\n                          <\/div>\r\n                        <\/div>\r\n                      <\/div>\r\n                                      <\/details>\r\n\r\n                \r\n                  <details class=\"liste-modeles__acc has-media \"\r\n                           >\r\n                    <summary class=\"liste-modeles__acc-summary\" >\r\n                      <span class=\"liste-modeles__acc-arrow\" aria-hidden=\"true\">\u2193<\/span>\r\n                      <span class=\"liste-modeles__acc-title\">ROTEM assay<\/span>\r\n                    <\/summary>\r\n\r\n                                          <div class=\"liste-modeles__acc-panel\">\r\n                        <div class=\"liste-modeles__acc-panel-inner\">\r\n                          <div class=\"liste-modeles__acc-grid \">\r\n\r\n                            <div class=\"liste-modeles__acc-content\">\r\n                              <div class=\"liste-modeles__acc-text\">\r\n                                \n<p>The ROTEM assay, performed on fresh human whole blood, measures the viscoelastic properties of the clot throughout its formation and subsequent lysis. A wide range of parameters can be extracted from the thromboelastogram, including the clotting time, the maximum clot firmness, and the 50% clot lysis time (LT50). This low-throughput assay offers an extensive and customisable set of hemostatic conditions for evaluating anticoagulant or thrombolytic compounds, including extrinsic or intrinsic activation pathways, as well as the addition of coagulation factors or modulators.   <\/p>\n\n<p>This assay also allows investigation of compound interactions when combined with reference fibrinolytics (Alteplase, Tenecteplase). <\/p>\n                              <\/div>\r\n\r\n                              \r\n                                                              <div class=\"liste-modeles__btnwrap\">\r\n                                  <a class=\"btn_secondary\" href=\"https:\/\/www.etap-lab.com\/en\/contact\/\">\r\n                                    Get the data sheet                                  <\/a>\r\n                                <\/div>\r\n                                                          <\/div>\r\n\r\n                                                          <div class=\"liste-modeles__acc-media\" aria-hidden=\"true\">\r\n                                <img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-rotem-1024x683.jpg\" class=\"liste-modeles__acc-img wp-post-image\" alt=\"invitro-screen displaying rotem test\" srcset=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-rotem-1024x683.jpg 1024w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-rotem-300x200.jpg 300w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-rotem-768x512.jpg 768w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-rotem-1536x1024.jpg 1536w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-rotem.jpg 1800w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>                              <\/div>\r\n                            \r\n                          <\/div>\r\n                        <\/div>\r\n                      <\/div>\r\n                                      <\/details>\r\n\r\n                              <\/div>\r\n\r\n              \r\n            \r\n          <\/div>\r\n\r\n        <\/article>\r\n      \r\n        <article class=\"liste-modeles__section\">\r\n\r\n          <div class=\"liste-modeles__section-head\">\r\n            <div class=\"liste-modeles__section-headtop\">\r\n                              <div class=\"liste-modeles__section-badge\" aria-hidden=\"true\">\r\n                  <img decoding=\"async\" class=\"liste-modeles__section-badge-img\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/02\/bxp-vitro-2.5.1-Neurones-primaires-Apoptose-Marquage-DAPI-Cleaved-Casp-3-and-MAP2-Modele-glutamate-Section-AVC-1024x1024.jpg\" alt=\"in vitro-Neurons-MAP2+Bassoon+PSD95+DAPI-Neurodeegeneration AB model\">\r\n                <\/div>\r\n              \r\n              <h2 id=\"cat-181\" class=\"liste-modeles__section-title\">\r\n                Neuroprotective screening              <\/h2>\r\n            <\/div>\r\n\r\n                      <\/div>\r\n\r\n          <div class=\"liste-modeles__section-body\">\r\n\r\n            \r\n              \r\n              <div class=\"liste-modeles__accordions\">\r\n                \r\n                  <details class=\"liste-modeles__acc has-media \"\r\n                           >\r\n                    <summary class=\"liste-modeles__acc-summary\" >\r\n                      <span class=\"liste-modeles__acc-arrow\" aria-hidden=\"true\">\u2193<\/span>\r\n                      <span class=\"liste-modeles__acc-title\">Glutamate-induced toxicity : 2D culture<\/span>\r\n                    <\/summary>\r\n\r\n                                          <div class=\"liste-modeles__acc-panel\">\r\n                        <div class=\"liste-modeles__acc-panel-inner\">\r\n                          <div class=\"liste-modeles__acc-grid \">\r\n\r\n                            <div class=\"liste-modeles__acc-content\">\r\n                              <div class=\"liste-modeles__acc-text\">\r\n                                \n<p>Our 2D excitotoxicity model provides a rapid and reliable platform to screen neuroprotective compounds in primary rodent neuronal cultures exposed to glutamate overload, <a>with MK801 as a reference compound<\/a>.<\/p>\n\n<p>Our high\u2011content imaging platform supports <strong>medium\u2011throughput<\/strong> screening of glutamate\u2011induced effects at both acute excitotoxic concentrations and sub-toxic levels that reduce synaptic density or disrupt neuritic network organisation. <\/p>\n\n<p>Excitotoxicity is a key pathophysiological mechanism within the ischemic cascade following stroke. It emerges within minutes to hours of stroke onset and persists throughout post\u2011ischemic phases (inflammation, synaptic remodelling, and epileptogenic hyperexcitability). <\/p>\n\n<p><\/p>\n                              <\/div>\r\n\r\n                              \r\n                                                              <div class=\"liste-modeles__btnwrap\">\r\n                                  <a class=\"btn_secondary\" href=\"https:\/\/www.etap-lab.com\/en\/contact\/\">\r\n                                    Get the data sheet                                  <\/a>\r\n                                <\/div>\r\n                                                          <\/div>\r\n\r\n                                                          <div class=\"liste-modeles__acc-media\" aria-hidden=\"true\">\r\n                                <img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/Vehicle-MAP2-1024x1024.jpg\" class=\"liste-modeles__acc-img wp-post-image\" alt=\"result of toxicity induced by glutamate on 2D in vitro culture\" srcset=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/Vehicle-MAP2-1024x1024.jpg 1024w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/Vehicle-MAP2-300x300.jpg 300w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/Vehicle-MAP2-150x150.jpg 150w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/Vehicle-MAP2-768x768.jpg 768w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/Vehicle-MAP2.jpg 1080w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>                              <\/div>\r\n                            \r\n                          <\/div>\r\n                        <\/div>\r\n                      <\/div>\r\n                                      <\/details>\r\n\r\n                \r\n                  <details class=\"liste-modeles__acc has-media \"\r\n                           >\r\n                    <summary class=\"liste-modeles__acc-summary\" >\r\n                      <span class=\"liste-modeles__acc-arrow\" aria-hidden=\"true\">\u2193<\/span>\r\n                      <span class=\"liste-modeles__acc-title\">Glutamate-induced toxicity: organ-on-chip<\/span>\r\n                    <\/summary>\r\n\r\n                                          <div class=\"liste-modeles__acc-panel\">\r\n                        <div class=\"liste-modeles__acc-panel-inner\">\r\n                          <div class=\"liste-modeles__acc-grid \">\r\n\r\n                            <div class=\"liste-modeles__acc-content\">\r\n                              <div class=\"liste-modeles__acc-text\">\r\n                                \n<p>Excitotoxicity is a key pathophysiological mechanism in ischemic stroke and contributes significantly to the consolidation of brain injury at sites distant from the ischemic core.<\/p>\n\n<p>Our brain\u2011on\u2011chip model is designed to reproduce secondary excitotoxicity by delivering glutamate specifically into a synaptic chamber located at the interface between two spatially separated neuronal populations (i.e. each maintained in its own microphysiological environments). <\/p>\n\n<p>Our microfluidic platform, combined with high\u2011content imaging, enables <strong>medium\u2011throughput<\/strong> screening of the effects of your compound on an isolated synapse, physically distant from the soma and exposed to excessive glutamate.<a id=\"_msocom_1\"><\/a><\/p>\n\n<p><\/p>\n                              <\/div>\r\n\r\n                              \r\n                                                              <div class=\"liste-modeles__btnwrap\">\r\n                                  <a class=\"btn_secondary\" href=\"https:\/\/www.etap-lab.com\/en\/contact\/\">\r\n                                    Get the data sheet                                  <\/a>\r\n                                <\/div>\r\n                                                          <\/div>\r\n\r\n                                                          <div class=\"liste-modeles__acc-media\" aria-hidden=\"true\">\r\n                                <img loading=\"lazy\" decoding=\"async\" width=\"540\" height=\"540\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/\u00b5fluidique.png\" class=\"liste-modeles__acc-img wp-post-image\" alt=\"\u00b5fluidique\" srcset=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/\u00b5fluidique.png 540w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/\u00b5fluidique-300x300.png 300w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/\u00b5fluidique-150x150.png 150w\" sizes=\"auto, (max-width: 540px) 100vw, 540px\" \/>                              <\/div>\r\n                            \r\n                          <\/div>\r\n                        <\/div>\r\n                      <\/div>\r\n                                      <\/details>\r\n\r\n                \r\n                  <details class=\"liste-modeles__acc no-media \"\r\n                           >\r\n                    <summary class=\"liste-modeles__acc-summary\" >\r\n                      <span class=\"liste-modeles__acc-arrow\" aria-hidden=\"true\">\u2193<\/span>\r\n                      <span class=\"liste-modeles__acc-title\">Glutamate uptake by astrocytes<\/span>\r\n                    <\/summary>\r\n\r\n                                          <div class=\"liste-modeles__acc-panel\">\r\n                        <div class=\"liste-modeles__acc-panel-inner\">\r\n                          <div class=\"liste-modeles__acc-grid is-full\">\r\n\r\n                            <div class=\"liste-modeles__acc-content\">\r\n                              <div class=\"liste-modeles__acc-text\">\r\n                                \n<p>Astrocytes play a central role in maintaining synaptic homeostasis and preventing excitotoxicity by clearing excess extracellular glutamate. This protective function becomes impaired in reactive astrocytes during the post-ischemic inflammatory phase.  <\/p>\n\n<p>Our <strong>astrogliosis model<\/strong> enables the screening of your compounds <strong>targeting glutamate uptake<\/strong> in <strong>human astrocytes (iPSC)<\/strong> activated with a cytokines cocktail. Activation of the <strong>NF\u03baB<\/strong> pathway is also available as a routine readout through our high-content imaging platform. <\/p>\n\n<p><\/p>\n                              <\/div>\r\n\r\n                              \r\n                                                              <div class=\"liste-modeles__btnwrap\">\r\n                                  <a class=\"btn_secondary\" href=\"https:\/\/www.etap-lab.com\/en\/contact\/\">\r\n                                    Get the data sheet                                  <\/a>\r\n                                <\/div>\r\n                                                          <\/div>\r\n\r\n                            \r\n                          <\/div>\r\n                        <\/div>\r\n                      <\/div>\r\n                                      <\/details>\r\n\r\n                              <\/div>\r\n\r\n              \r\n            \r\n          <\/div>\r\n\r\n        <\/article>\r\n      \r\n        <article class=\"liste-modeles__section\">\r\n\r\n          <div class=\"liste-modeles__section-head\">\r\n            <div class=\"liste-modeles__section-headtop\">\r\n                              <div class=\"liste-modeles__section-badge\" aria-hidden=\"true\">\r\n                  <img decoding=\"async\" class=\"liste-modeles__section-badge-img\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/work-environment2-1024x683.jpg\" alt=\"work-environment lab\">\r\n                <\/div>\r\n              \r\n              <h2 id=\"cat-180\" class=\"liste-modeles__section-title\">\r\n                Pharmacological interaction and hemostasis              <\/h2>\r\n            <\/div>\r\n\r\n                      <\/div>\r\n\r\n          <div class=\"liste-modeles__section-body\">\r\n\r\n            \r\n              \r\n              <div class=\"liste-modeles__accordions\">\r\n                \r\n                  <details class=\"liste-modeles__acc has-media \"\r\n                           >\r\n                    <summary class=\"liste-modeles__acc-summary\" >\r\n                      <span class=\"liste-modeles__acc-arrow\" aria-hidden=\"true\">\u2193<\/span>\r\n                      <span class=\"liste-modeles__acc-title\">Clot lysis assay<\/span>\r\n                    <\/summary>\r\n\r\n                                          <div class=\"liste-modeles__acc-panel\">\r\n                        <div class=\"liste-modeles__acc-panel-inner\">\r\n                          <div class=\"liste-modeles__acc-grid \">\r\n\r\n                            <div class=\"liste-modeles__acc-content\">\r\n                              <div class=\"liste-modeles__acc-text\">\r\n                                \n<p>Documenting potential interactions between reference fibrinolytics and drug candidates is required by regulatory agencies when these treatments are intended for combined administration during the acute phase of stroke. <\/p>\n\n<p>Using turbidimetry in 96-well plates, the clot lysis assay quantifies fibrinolytic activity in human plasma pools, relying on parameters such as the 50% clot lysis time (LT50). The high reproducibility of the assay ensures reliable and straightforward comparison of dose-response curves for Alteplase or Tenecteplase, either alone or in combination with multiple concentrations of your compound.  <\/p>\n\n<p><\/p>\n                              <\/div>\r\n\r\n                              \r\n                                                              <div class=\"liste-modeles__btnwrap\">\r\n                                  <a class=\"btn_secondary\" href=\"https:\/\/www.etap-lab.com\/en\/contact\/\">\r\n                                    Get the data sheet                                  <\/a>\r\n                                <\/div>\r\n                                                          <\/div>\r\n\r\n                                                          <div class=\"liste-modeles__acc-media\" aria-hidden=\"true\">\r\n                                <img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-clotlysis-1024x683.jpg\" class=\"liste-modeles__acc-img wp-post-image\" alt=\"invitro-clotlysis assay in a lab blue\" srcset=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-clotlysis-1024x683.jpg 1024w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-clotlysis-300x200.jpg 300w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-clotlysis-768x512.jpg 768w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-clotlysis-1536x1024.jpg 1536w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-clotlysis.jpg 1800w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>                              <\/div>\r\n                            \r\n                          <\/div>\r\n                        <\/div>\r\n                      <\/div>\r\n                                      <\/details>\r\n\r\n                \r\n                  <details class=\"liste-modeles__acc has-media \"\r\n                           >\r\n                    <summary class=\"liste-modeles__acc-summary\" >\r\n                      <span class=\"liste-modeles__acc-arrow\" aria-hidden=\"true\">\u2193<\/span>\r\n                      <span class=\"liste-modeles__acc-title\">ROTEM assay<\/span>\r\n                    <\/summary>\r\n\r\n                                          <div class=\"liste-modeles__acc-panel\">\r\n                        <div class=\"liste-modeles__acc-panel-inner\">\r\n                          <div class=\"liste-modeles__acc-grid \">\r\n\r\n                            <div class=\"liste-modeles__acc-content\">\r\n                              <div class=\"liste-modeles__acc-text\">\r\n                                \n<p>This assay also allows investigation of compound interactions when combined with reference fibrinolytics (Alteplase, Tenecteplase). <\/p>\n\n<p>The ROTEM assay, performed on fresh human whole blood, measures the viscoelastic properties of the clot throughout its formation and subsequent lysis. <\/p>\n\n<p>A wide range of parameters can be extracted from the thromboelastogram, including the clotting time, the maximum clot firmness, and the 50% clot lysis time (LT50). This low-throughput assay offers an extensive and customisable set of hemostatic conditions for evaluating anticoagulant or thrombolytic compounds, including extrinsic or intrinsic activation pathways, as well as the addition of coagulation factors or modulators.   <\/p>\n                              <\/div>\r\n\r\n                              \r\n                                                              <div class=\"liste-modeles__btnwrap\">\r\n                                  <a class=\"btn_secondary\" href=\"https:\/\/www.etap-lab.com\/en\/contact\/\">\r\n                                    Get the data sheet                                  <\/a>\r\n                                <\/div>\r\n                                                          <\/div>\r\n\r\n                                                          <div class=\"liste-modeles__acc-media\" aria-hidden=\"true\">\r\n                                <img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-rotem-1024x683.jpg\" class=\"liste-modeles__acc-img wp-post-image\" alt=\"invitro-screen displaying rotem test\" srcset=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-rotem-1024x683.jpg 1024w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-rotem-300x200.jpg 300w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-rotem-768x512.jpg 768w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-rotem-1536x1024.jpg 1536w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/invitro-rotem.jpg 1800w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>                              <\/div>\r\n                            \r\n                          <\/div>\r\n                        <\/div>\r\n                      <\/div>\r\n                                      <\/details>\r\n\r\n                              <\/div>\r\n\r\n              \r\n            \r\n          <\/div>\r\n\r\n        <\/article>\r\n      \r\n    \r\n  <\/div>\r\n<\/section><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\r\n<section id=\"nos-plateformes\" class=\"nos-plateformes alignfull is-theme-light\">\r\n\r\n  <!-- GRID -->\r\n      <div class=\"nos-plateformes__gridZone\">\r\n      <div class=\"nos-plateformes__container\">\r\n\r\n        <div class=\"np-grid\" role=\"list\" aria-label=\"Liste des plateformes\">\r\n\r\n          \r\n            <a class=\"np-item\" role=\"listitem\" href=\"https:\/\/www.etap-lab.com\/services-cro\/nos-plateformes\/#high-content-imaging\">\r\n\r\n                              <div class=\"np-item__img\">\r\n                  <img\r\n                    src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/04\/Plateforme_Vitro_Pastille-High-Content-1024x683.jpg\"\r\n                    alt=\"high content imaging results neurology\"\r\n                    loading=\"lazy\"\r\n                    decoding=\"async\"\r\n                  >\r\n                <\/div>\r\n              \r\n              <div class=\"np-item__content\">\r\n                <h3 class=\"np-item__title\">High-Content Imaging<\/h3>\r\n\r\n                                  <div class=\"np-item__desc\">ETAP-LAB provides a wide range of morphological and functional readouts within complex cellular models through High-Content Imaging technologies. Using the Operetta CLS&trade; platform (Revvity), we automate medium&#8209;throughput fluorescence imaging and integrate AI&#8209;enhanced image&#8209;analysis pipelines to deliver rapid, high&#8209;accuracy quantification of large datasets. Entrust your screening and lead-optimization campaigns to an expert team.<\/div>\r\n                              <\/div>\r\n\r\n              <span class=\"np-item__arrow\" aria-hidden=\"true\">\r\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"42\" height=\"42\" viewBox=\"0 0 42 42\" fill=\"none\">\r\n                  <g clip-path=\"url(#clip0_np_arrow)\">\r\n                    <path d=\"M32.897 8.58183L15.4112 8.90396L15.3839 10.3675L28.9215 10.1176C29.4568 10.1091 29.7131 10.7504 29.3282 11.1353L8.07416 32.3894L9.0895 33.4047L30.342 12.1522C30.7269 11.7673 31.3697 12.0221 31.3597 12.5589L31.1098 26.0965L32.5734 26.0692L32.8955 8.58336L32.897 8.58183Z\"\r\n                          fill=\"currentColor\"\/>\r\n                  <\/g>\r\n                  <defs>\r\n                    <clipPath id=\"clip0_np_arrow\">\r\n                      <rect width=\"34.3869\" height=\"24.2731\" fill=\"white\" transform=\"translate(0 24.3152) rotate(-45)\"\/>\r\n                    <\/clipPath>\r\n                  <\/defs>\r\n                <\/svg>\r\n              <\/span>\r\n\r\n            <\/a>\r\n\r\n          \r\n            <a class=\"np-item\" role=\"listitem\" href=\"https:\/\/www.etap-lab.com\/services-cro\/nos-plateformes\/#brain-on-chip-platform\">\r\n\r\n                              <div class=\"np-item__img\">\r\n                  <img\r\n                    src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/04\/Plateforme_Vitro_High-Content_Photo-3_Quantif-1024x683.jpg\"\r\n                    alt=\"high content imaging of in vitro results\"\r\n                    loading=\"lazy\"\r\n                    decoding=\"async\"\r\n                  >\r\n                <\/div>\r\n              \r\n              <div class=\"np-item__content\">\r\n                <h3 class=\"np-item__title\">Brain\u2011on\u2011Chip platform<\/h3>\r\n\r\n                                  <div class=\"np-item__desc\">For several years, ETAP&#8209;LAB has been investing in R&amp;D programs aimed to engineer and scale-up brain&#8209;on&#8209;chip platforms, contributing to their routine adoption in preclinical CNS pharmacology. Built on compartmentalized microfluidic architectures, our brain&#8209;on&#8209;chip systems recreate the connectivity between spatially distinct neuronal populations maintained in different controlled microphysiological environments. This approach overcomes key limitations inherent to [&hellip;]<\/div>\r\n                              <\/div>\r\n\r\n              <span class=\"np-item__arrow\" aria-hidden=\"true\">\r\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"42\" height=\"42\" viewBox=\"0 0 42 42\" fill=\"none\">\r\n                  <g clip-path=\"url(#clip0_np_arrow)\">\r\n                    <path d=\"M32.897 8.58183L15.4112 8.90396L15.3839 10.3675L28.9215 10.1176C29.4568 10.1091 29.7131 10.7504 29.3282 11.1353L8.07416 32.3894L9.0895 33.4047L30.342 12.1522C30.7269 11.7673 31.3697 12.0221 31.3597 12.5589L31.1098 26.0965L32.5734 26.0692L32.8955 8.58336L32.897 8.58183Z\"\r\n                          fill=\"currentColor\"\/>\r\n                  <\/g>\r\n                  <defs>\r\n                    <clipPath id=\"clip0_np_arrow\">\r\n                      <rect width=\"34.3869\" height=\"24.2731\" fill=\"white\" transform=\"translate(0 24.3152) rotate(-45)\"\/>\r\n                    <\/clipPath>\r\n                  <\/defs>\r\n                <\/svg>\r\n              <\/span>\r\n\r\n            <\/a>\r\n\r\n          \r\n            <a class=\"np-item\" role=\"listitem\" href=\"https:\/\/www.etap-lab.com\/services-cro\/nos-plateformes\/#small-and-large-animal-facilities\">\r\n\r\n                              <div class=\"np-item__img\">\r\n                  <img\r\n                    src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/02\/ETL-EN-1-header-2-1024x683.jpg\"\r\n                    alt=\"red light animal room\"\r\n                    loading=\"lazy\"\r\n                    decoding=\"async\"\r\n                  >\r\n                <\/div>\r\n              \r\n              <div class=\"np-item__content\">\r\n                <h3 class=\"np-item__title\">Small and Large Animal Facilities<\/h3>\r\n\r\n                                  <div class=\"np-item__desc\">ETAP&#8209;LAB operates 1,000 m&sup2; of fully accredited facilities (A1\/A2 level), distributed across three sites with a total housing capacity of approximately 1,200 rodents. Our facilities are also authorized for Class 1 genetically modified mice and immunodeficient strains (NUDE and humanized). Each facility includes controlled&#8209;environment housing rooms, dedicated zootechnical areas, microsurgery platforms, and experimental rooms fully [&hellip;]<\/div>\r\n                              <\/div>\r\n\r\n              <span class=\"np-item__arrow\" aria-hidden=\"true\">\r\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"42\" height=\"42\" viewBox=\"0 0 42 42\" fill=\"none\">\r\n                  <g clip-path=\"url(#clip0_np_arrow)\">\r\n                    <path d=\"M32.897 8.58183L15.4112 8.90396L15.3839 10.3675L28.9215 10.1176C29.4568 10.1091 29.7131 10.7504 29.3282 11.1353L8.07416 32.3894L9.0895 33.4047L30.342 12.1522C30.7269 11.7673 31.3697 12.0221 31.3597 12.5589L31.1098 26.0965L32.5734 26.0692L32.8955 8.58336L32.897 8.58183Z\"\r\n                          fill=\"currentColor\"\/>\r\n                  <\/g>\r\n                  <defs>\r\n                    <clipPath id=\"clip0_np_arrow\">\r\n                      <rect width=\"34.3869\" height=\"24.2731\" fill=\"white\" transform=\"translate(0 24.3152) rotate(-45)\"\/>\r\n                    <\/clipPath>\r\n                  <\/defs>\r\n                <\/svg>\r\n              <\/span>\r\n\r\n            <\/a>\r\n\r\n          \r\n            <a class=\"np-item\" role=\"listitem\" href=\"https:\/\/www.etap-lab.com\/services-cro\/nos-plateformes\/#preclinical-medical-imaging\">\r\n\r\n                              <div class=\"np-item__img\">\r\n                  <img\r\n                    src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/02\/photo-3-bis-CAEN.jpg\"\r\n                    alt=\"irm live on a screen\"\r\n                    loading=\"lazy\"\r\n                    decoding=\"async\"\r\n                  >\r\n                <\/div>\r\n              \r\n              <div class=\"np-item__content\">\r\n                <h3 class=\"np-item__title\">Preclinical Medical Imaging<\/h3>\r\n\r\n                                  <div class=\"np-item__desc\">Through our long&#8209;standing partnership with the CYCERON imaging platform in Caen, located directly next to our facilities, we have privileged access to state&#8209;of&#8209;the&#8209;art medical imaging tools within an internationally recognized infrastructure. ETAP&#8209;LAB teams &ndash; trained, autonomous, and experienced &ndash; routinely use the following systems: A 7T MRI for high&#8209;resolution anatomical and functional imaging in rodents, [&hellip;]<\/div>\r\n                              <\/div>\r\n\r\n              <span class=\"np-item__arrow\" aria-hidden=\"true\">\r\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"42\" height=\"42\" viewBox=\"0 0 42 42\" fill=\"none\">\r\n                  <g clip-path=\"url(#clip0_np_arrow)\">\r\n                    <path d=\"M32.897 8.58183L15.4112 8.90396L15.3839 10.3675L28.9215 10.1176C29.4568 10.1091 29.7131 10.7504 29.3282 11.1353L8.07416 32.3894L9.0895 33.4047L30.342 12.1522C30.7269 11.7673 31.3697 12.0221 31.3597 12.5589L31.1098 26.0965L32.5734 26.0692L32.8955 8.58336L32.897 8.58183Z\"\r\n                          fill=\"currentColor\"\/>\r\n                  <\/g>\r\n                  <defs>\r\n                    <clipPath id=\"clip0_np_arrow\">\r\n                      <rect width=\"34.3869\" height=\"24.2731\" fill=\"white\" transform=\"translate(0 24.3152) rotate(-45)\"\/>\r\n                    <\/clipPath>\r\n                  <\/defs>\r\n                <\/svg>\r\n              <\/span>\r\n\r\n            <\/a>\r\n\r\n          \r\n            <a class=\"np-item\" role=\"listitem\" href=\"https:\/\/www.etap-lab.com\/services-cro\/nos-plateformes\/#immunohistochemistry-immunofluorescence-and-histology\">\r\n\r\n                              <div class=\"np-item__img\">\r\n                  <img\r\n                    src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/02\/galeriephoto-microscopie-violet-Laboratoire-1024x683.jpg\"\r\n                    alt=\"microscopy-violet-Laboratory\"\r\n                    loading=\"lazy\"\r\n                    decoding=\"async\"\r\n                  >\r\n                <\/div>\r\n              \r\n              <div class=\"np-item__content\">\r\n                <h3 class=\"np-item__title\">Immunohistochemistry, Immunofluorescence, and Histology<\/h3>\r\n\r\n                                  <div class=\"np-item__desc\">Our fully integrated IHC, immunofluorescence, and histology platform manages the entire workflow &ndash; from tissue collection to data interpretation &ndash; ensuring coordination with our in vivo platform and preserving sample integrity throughout. This end-to-end know-how enables reduced turnaround times and reliable analyses across a panel of pre-validated biomarkers. We process frozen tissues, including cryo&#8209;embedding and [&hellip;]<\/div>\r\n                              <\/div>\r\n\r\n              <span class=\"np-item__arrow\" aria-hidden=\"true\">\r\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"42\" height=\"42\" viewBox=\"0 0 42 42\" fill=\"none\">\r\n                  <g clip-path=\"url(#clip0_np_arrow)\">\r\n                    <path d=\"M32.897 8.58183L15.4112 8.90396L15.3839 10.3675L28.9215 10.1176C29.4568 10.1091 29.7131 10.7504 29.3282 11.1353L8.07416 32.3894L9.0895 33.4047L30.342 12.1522C30.7269 11.7673 31.3697 12.0221 31.3597 12.5589L31.1098 26.0965L32.5734 26.0692L32.8955 8.58336L32.897 8.58183Z\"\r\n                          fill=\"currentColor\"\/>\r\n                  <\/g>\r\n                  <defs>\r\n                    <clipPath id=\"clip0_np_arrow\">\r\n                      <rect width=\"34.3869\" height=\"24.2731\" fill=\"white\" transform=\"translate(0 24.3152) rotate(-45)\"\/>\r\n                    <\/clipPath>\r\n                  <\/defs>\r\n                <\/svg>\r\n              <\/span>\r\n\r\n            <\/a>\r\n\r\n          \r\n            <a class=\"np-item\" role=\"listitem\" href=\"https:\/\/www.etap-lab.com\/services-cro\/nos-plateformes\/#immunoassays\">\r\n\r\n                              <div class=\"np-item__img\">\r\n                  <img\r\n                    src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/04\/Plateforme_Analyses-bio_Pastille-Immunodosage_Plaque-coloree-1024x683.jpg\"\r\n                    alt=\"bioassay Colorimetric Immunoassay purple\"\r\n                    loading=\"lazy\"\r\n                    decoding=\"async\"\r\n                  >\r\n                <\/div>\r\n              \r\n              <div class=\"np-item__content\">\r\n                <h3 class=\"np-item__title\">Immunoassays<\/h3>\r\n\r\n                                  <div class=\"np-item__desc\">Our integrated immunoassay platform ensures a continuous workflow coordinated with our in vitro and in vivo platforms, enabling uncompromised sample integrity, shortening timelines, and delivering reliable analyses across a panel of prevalidated biomarkers. We routinely perform protein and enzymatic&#8209;activity quantification using standardized colorimetric, fluorescent, and luminescent detection methods accross multiple sample types, including tissues, biological [&hellip;]<\/div>\r\n                              <\/div>\r\n\r\n              <span class=\"np-item__arrow\" aria-hidden=\"true\">\r\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"42\" height=\"42\" viewBox=\"0 0 42 42\" fill=\"none\">\r\n                  <g clip-path=\"url(#clip0_np_arrow)\">\r\n                    <path d=\"M32.897 8.58183L15.4112 8.90396L15.3839 10.3675L28.9215 10.1176C29.4568 10.1091 29.7131 10.7504 29.3282 11.1353L8.07416 32.3894L9.0895 33.4047L30.342 12.1522C30.7269 11.7673 31.3697 12.0221 31.3597 12.5589L31.1098 26.0965L32.5734 26.0692L32.8955 8.58336L32.897 8.58183Z\"\r\n                          fill=\"currentColor\"\/>\r\n                  <\/g>\r\n                  <defs>\r\n                    <clipPath id=\"clip0_np_arrow\">\r\n                      <rect width=\"34.3869\" height=\"24.2731\" fill=\"white\" transform=\"translate(0 24.3152) rotate(-45)\"\/>\r\n                    <\/clipPath>\r\n                  <\/defs>\r\n                <\/svg>\r\n              <\/span>\r\n\r\n            <\/a>\r\n\r\n          \r\n        <\/div>\r\n\r\n      <\/div>\r\n    <\/div>\r\n  \r\n<\/section><\/div>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--80);padding-bottom:var(--wp--preset--spacing--80)\">\r\n<section id=\"texte-image-block_d24c93abce8af648159eed950c02759e\" class=\"texte-image alignfull is-theme-light is-image-right is-image-round\">\r\n  <div class=\"texte-image__grid\">\r\n\r\n    <div class=\"texte-image__container\">\r\n      <div class=\"texte-image__content\">\r\n\r\n        \r\n                  <h2 class=\"texte-image__title\">The effects of your molecules can be evaluated through complementary and multi-scale approaches.\n<\/h2>\r\n        \r\n        \r\n        \r\n                  <div class=\"texte-image__cta\">\r\n            <a class=\"btn_secondary\" href=\"https:\/\/www.etap-lab.com\/contact\/\">Contact an expert<\/a>\r\n          <\/div>\r\n        \r\n        \r\n      <\/div>\r\n    <\/div>\r\n\r\n          <div class=\"texte-image__media\">\r\n        <div class=\"texte-image__media-frame\">\r\n          <img\r\n            src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/02\/galeriephoto-microscopie-violet-Laboratoire.jpg\"\r\n            alt=\"In vitro models \u2013 galeriephoto microscopie violet laboratoire\"\r\n            loading=\"lazy\"\r\n            decoding=\"async\"\r\n          >\r\n        <\/div>\r\n      <\/div>\r\n    \r\n  <\/div>\r\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>in vitro pharmacology models in Neurovascular &amp; Stroke With STROK@LLIANCE, accelerate the development of your ischemic and hemorrhagic stroke therapies with our preclinical in vitro models based on primary neuronal cultures and human blood-based assays. We support you in:<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":3081,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3286","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>in vitro pharmacology models in Neurovascular &amp; Stroke - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Accelerate the development of your ischemic and hemorrhagic stroke therapies with STROK@LLIANCE - Preclinical in vitro services.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vitro-models\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"in vitro pharmacology models in Neurovascular &amp; 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