{"id":16311,"date":"2018-11-02T10:12:21","date_gmt":"2018-11-02T10:12:21","guid":{"rendered":"http:\/\/www.strokalliance.com\/?p=6311"},"modified":"2026-04-17T18:09:02","modified_gmt":"2026-04-17T16:09:02","slug":"impact-of-bradykinin-generation-during-thrombolysis-in-ischemic-stroke","status":"publish","type":"post","link":"https:\/\/www.etap-lab.com\/en\/corporate\/impact-of-bradykinin-generation-during-thrombolysis-in-ischemic-stroke\/","title":{"rendered":"Impact of Bradykinin Generation During Thrombolysis in Ischemic Stroke"},"content":{"rendered":"<p style=\"text-align: justify;\"><span id=\"ember1304\" class=\"ember-view\">A very interesting review have been published by our Caen academic partner (PhIND unit, <\/span><a id=\"ember1308\" class=\"tap-target feed-shared-text-view__mention ember-view\" href=\"https:\/\/www.linkedin.com\/school\/12493\/?legacySchoolId=12493\" target=\"_self\" rel=\"noopener noreferrer\"><span data-entity-hovercard-id=\"urn:li:fs_miniSchool:12493\">Universit\u00e9 de Caen Normandie<\/span><\/a><span id=\"ember1312\" class=\"ember-view\"> \/ <\/span><a id=\"ember1316\" class=\"tap-target feed-shared-text-view__mention ember-view\" href=\"https:\/\/www.linkedin.com\/company\/8066\/\" target=\"_self\" rel=\"noopener noreferrer\"><span data-entity-hovercard-id=\"urn:li:fs_miniCompany:8066\">INSERM<\/span><\/a><span id=\"ember1320\" class=\"ember-view\"> ) concerning the current evidence linking tPA mediated thrombolysis, bradykinin generation and potential subsequent neurovascular damages. While tPA is an important pharmacological tool for acute stroke management, this clot buster also promotes hemorrhagic transformation, symptomatic cerebral edema and angioedema. Preclinical and clinical evidence suggests that intravenous thrombolysis generates large amounts of bradykinin, a peptide with potent pro-inflammatory, and pro-edematous effects. Thus, this tPA-induced generation of bradykinin is a potential target to improve neurological outcome after thrombolysis.<\/span><\/p>\n<p style=\"text-align: justify;\"><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6037726\/\">Link to the article<\/a><\/strong><\/p>\n<p style=\"text-align: justify;\">\n","protected":false},"excerpt":{"rendered":"<p>Impact of Bradykinin Generation During Thrombolysis in Ischemic Stroke<\/p>\n","protected":false},"author":13,"featured_media":5853,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[205],"tags":[],"aire-therapeutique":[230],"class_list":["post-16311","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-corporate","aire-therapeutique-neurovasculaire-avc"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Impact of Bradykinin Generation During Thrombolysis in Ischemic Stroke - 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