Preclinical data collected in models of preclinical Parkinson disease (PD) support the neuroprotective potential of omega-3 polyunsaturated fatty acids (n-3 PUFA)-enriched diet on the dopaminergic (DAergic) system. In this study, we investigated the effects of a n-3 PUFA rich diet using a neurorescue\/neurorestorative paradigm. C57BL\/6 adult mice were submitted to a striatal stereotaxic injection of the neurotoxin 6-hydroxydopamine (6-OHDA) to induce DAergic denervation and subsequent nigral DAergic cell loss. Three weeks post-lesion, mice received either a docosahexaenoic acid (DHA)-enriched or a control diet for a period of 6 weeks. HPLC analyses revealed a 52 % post-lesion increase in striatal dopamine levels in the DHA-fed animals compared to controls (ctrl, P<0.05), although no improvement in the motor behavior was observed. DHA treatment led to a 47 % rise in tyrosine-hydroxylase (TH) - immunoreactive terminals within the striatum (P<0.05) in lesioned animals. Despite the fact that DHA did not change the number of TH+ neurons in the substantia nigra pars compacta (SNpc), morphological analyses revealed an increased in perimeters (+6%) and areas (+17) of DAergic cell bodies in treated animals. Collectively, our results suggest that DHA induce a partial neurorescue\/neurorestoration of the DAergic system and support further studies to investigate the potential of a diet-based intervention, or at least the combination of such approach, to current treatments in PD.\n\nAbout the article:\nhttp:\/\/dx.doi.org\/10.1016\/j.jnutbio.2015.11.014\n\nAbout Syncrosome:\nSyncrosome is a scientific preclinical CRO based in France focused on validating animal disease models to assess the efficacy of new compounds in the field of CNS, Cardiovascular, Gastrointestinal and Respiratory diseases.\n\n<\/p>\n","protected":false},"excerpt":{"rendered":"
Discover Neurorescue and DHA on a 6OHDA preclinical Parkinson model: Preclinical data collected in models of preclinical Parkinson disease (PD) support the neuroprotective potential of\u2026<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[207],"tags":[],"aire-therapeutique":[229],"class_list":["post-17041","post","type-post","status-publish","format-standard","hentry","category-science-and-innovation","aire-therapeutique-neurologie-cns"],"acf":[],"yoast_head":"\n