{"id":32028,"date":"2020-10-19T14:39:01","date_gmt":"2020-10-19T14:39:01","guid":{"rendered":"https:\/\/www.etap-lab.com\/?p=12028"},"modified":"2026-04-17T18:15:02","modified_gmt":"2026-04-17T16:15:02","slug":"tau-oligomer-toxicity-our-first-data","status":"publish","type":"post","link":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/","title":{"rendered":"Tau oligomer toxicity – our first data!"},"content":{"rendered":"\n

The new tau oligomers produced by ETAP-Lab show reproducible and dose-dependent toxicity on rodent primary neuron cultures.<\/p>\n\n\n\n

Promising and repeatedly replicated data show that tau oligomers exhibit dose-dependent toxicity that is not observed with equivalent monomer concentrations. At high concentrations, the oligomers completely destabilise the neurons, leading to a rapid mortality rate of 100%.<\/p>\n\n\n\n

 <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

<\/p>\n\n\n\n

 <\/p>\n\n\n\n

Now that the main technical obstacles have been overcome, a validated model for pharmacological screening should be ready soon. The next step is to evaluate some reference compounds. The first BDNF results are expected within a couple of weeks.<\/p>\n\n\n\n

Keep up with our in vitro activity by following our ETAP-Lab page Follow us on LinkedIn<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Discover Tau oligomer toxicity – our first data!: The new tau oligomers produced by ETAP-Lab show reproducible and dose-dependent toxicity on rodent primary neuron cultures.<\/p>\n","protected":false},"author":13,"featured_media":4060,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[207],"tags":[],"aire-therapeutique":[],"class_list":["post-32028","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-innovation"],"acf":[],"yoast_head":"\nTau oligomer toxicity - our first data! - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Discover Tau oligomer toxicity - our first data!: The new tau oligomers produced by ETAP-Lab show reproducible and dose-dependent toxicity on rodent primary neuron cultures.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tau oligomer toxicity - our first data! - ETAP-LAB\" \/>\n<meta property=\"og:description\" content=\"Discover Tau oligomer toxicity - our first data!: The new tau oligomers produced by ETAP-Lab show reproducible and dose-dependent toxicity on rodent primary neuron cultures.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/\" \/>\n<meta property=\"og:site_name\" content=\"ETAP-LAB\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-19T14:39:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-17T16:15:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Tau-monomer-VS-oligomer-pub.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"596\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Ana\u00efs GAVOILLE\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ana\u00efs GAVOILLE\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/science-and-innovation\\\/tau-oligomer-toxicity-our-first-data\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/science-and-innovation\\\/tau-oligomer-toxicity-our-first-data\\\/\"},\"author\":{\"name\":\"Ana\u00efs GAVOILLE\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#\\\/schema\\\/person\\\/5795847a84eb95e1faecaac7eaf85ba9\"},\"headline\":\"Tau oligomer toxicity – our first data!\",\"datePublished\":\"2020-10-19T14:39:01+00:00\",\"dateModified\":\"2026-04-17T16:15:02+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/science-and-innovation\\\/tau-oligomer-toxicity-our-first-data\\\/\"},\"wordCount\":117,\"publisher\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/science-and-innovation\\\/tau-oligomer-toxicity-our-first-data\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2020\\\/12\\\/Tau-monomer-VS-oligomer-pub.png\",\"articleSection\":[\"Science and innovation\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/science-and-innovation\\\/tau-oligomer-toxicity-our-first-data\\\/\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/science-and-innovation\\\/tau-oligomer-toxicity-our-first-data\\\/\",\"name\":\"Tau oligomer toxicity - our first data! - ETAP-LAB\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/science-and-innovation\\\/tau-oligomer-toxicity-our-first-data\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/science-and-innovation\\\/tau-oligomer-toxicity-our-first-data\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2020\\\/12\\\/Tau-monomer-VS-oligomer-pub.png\",\"datePublished\":\"2020-10-19T14:39:01+00:00\",\"dateModified\":\"2026-04-17T16:15:02+00:00\",\"description\":\"Discover Tau oligomer toxicity - our first data!: The new tau oligomers produced by ETAP-Lab show reproducible and dose-dependent toxicity on rodent primary neuron cultures.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/science-and-innovation\\\/tau-oligomer-toxicity-our-first-data\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/science-and-innovation\\\/tau-oligomer-toxicity-our-first-data\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/science-and-innovation\\\/tau-oligomer-toxicity-our-first-data\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2020\\\/12\\\/Tau-monomer-VS-oligomer-pub.png\",\"contentUrl\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2020\\\/12\\\/Tau-monomer-VS-oligomer-pub.png\",\"width\":1200,\"height\":596},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/science-and-innovation\\\/tau-oligomer-toxicity-our-first-data\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Company\",\"item\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/corporate\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Tau oligomer toxicity – our first data!\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/\",\"name\":\"Etap Lab\",\"description\":\"CRO Services\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#organization\",\"name\":\"Etap Lab\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/etap-lab-etap-lab-preclinical-cro-right-full-color-rgb-1920px-w-72ppi.png\",\"contentUrl\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/etap-lab-etap-lab-preclinical-cro-right-full-color-rgb-1920px-w-72ppi.png\",\"width\":550,\"height\":550,\"caption\":\"Etap Lab\"},\"image\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.linkedin.com\\\/company\\\/etap-lab\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#\\\/schema\\\/person\\\/5795847a84eb95e1faecaac7eaf85ba9\",\"name\":\"Ana\u00efs GAVOILLE\",\"description\":\"Marketing expert at ETAP-LAB.\",\"sameAs\":[\"https:\\\/\\\/www.linkedin.com\\\/in\\\/anais-gavoille-54lorraine\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Tau oligomer toxicity - our first data! - ETAP-LAB","description":"Discover Tau oligomer toxicity - our first data!: The new tau oligomers produced by ETAP-Lab show reproducible and dose-dependent toxicity on rodent primary neuron cultures.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/","og_locale":"en_US","og_type":"article","og_title":"Tau oligomer toxicity - our first data! - ETAP-LAB","og_description":"Discover Tau oligomer toxicity - our first data!: The new tau oligomers produced by ETAP-Lab show reproducible and dose-dependent toxicity on rodent primary neuron cultures.","og_url":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/","og_site_name":"ETAP-LAB","article_published_time":"2020-10-19T14:39:01+00:00","article_modified_time":"2026-04-17T16:15:02+00:00","og_image":[{"width":1200,"height":596,"url":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Tau-monomer-VS-oligomer-pub.png","type":"image\/png"}],"author":"Ana\u00efs GAVOILLE","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Ana\u00efs GAVOILLE","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/#article","isPartOf":{"@id":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/"},"author":{"name":"Ana\u00efs GAVOILLE","@id":"https:\/\/www.etap-lab.com\/en\/#\/schema\/person\/5795847a84eb95e1faecaac7eaf85ba9"},"headline":"Tau oligomer toxicity – our first data!","datePublished":"2020-10-19T14:39:01+00:00","dateModified":"2026-04-17T16:15:02+00:00","mainEntityOfPage":{"@id":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/"},"wordCount":117,"publisher":{"@id":"https:\/\/www.etap-lab.com\/en\/#organization"},"image":{"@id":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/#primaryimage"},"thumbnailUrl":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Tau-monomer-VS-oligomer-pub.png","articleSection":["Science and innovation"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/","url":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/","name":"Tau oligomer toxicity - our first data! - ETAP-LAB","isPartOf":{"@id":"https:\/\/www.etap-lab.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/#primaryimage"},"image":{"@id":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/#primaryimage"},"thumbnailUrl":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Tau-monomer-VS-oligomer-pub.png","datePublished":"2020-10-19T14:39:01+00:00","dateModified":"2026-04-17T16:15:02+00:00","description":"Discover Tau oligomer toxicity - our first data!: The new tau oligomers produced by ETAP-Lab show reproducible and dose-dependent toxicity on rodent primary neuron cultures.","breadcrumb":{"@id":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/#primaryimage","url":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Tau-monomer-VS-oligomer-pub.png","contentUrl":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Tau-monomer-VS-oligomer-pub.png","width":1200,"height":596},{"@type":"BreadcrumbList","@id":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/tau-oligomer-toxicity-our-first-data\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.etap-lab.com\/en\/"},{"@type":"ListItem","position":2,"name":"Company","item":"https:\/\/www.etap-lab.com\/en\/corporate\/"},{"@type":"ListItem","position":3,"name":"Tau oligomer toxicity – our first data!"}]},{"@type":"WebSite","@id":"https:\/\/www.etap-lab.com\/en\/#website","url":"https:\/\/www.etap-lab.com\/en\/","name":"Etap Lab","description":"CRO Services","publisher":{"@id":"https:\/\/www.etap-lab.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.etap-lab.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.etap-lab.com\/en\/#organization","name":"Etap Lab","url":"https:\/\/www.etap-lab.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.etap-lab.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/etap-lab-etap-lab-preclinical-cro-right-full-color-rgb-1920px-w-72ppi.png","contentUrl":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/etap-lab-etap-lab-preclinical-cro-right-full-color-rgb-1920px-w-72ppi.png","width":550,"height":550,"caption":"Etap Lab"},"image":{"@id":"https:\/\/www.etap-lab.com\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.linkedin.com\/company\/etap-lab\/"]},{"@type":"Person","@id":"https:\/\/www.etap-lab.com\/en\/#\/schema\/person\/5795847a84eb95e1faecaac7eaf85ba9","name":"Ana\u00efs GAVOILLE","description":"Marketing expert at ETAP-LAB.","sameAs":["https:\/\/www.linkedin.com\/in\/anais-gavoille-54lorraine\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/posts\/32028","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/comments?post=32028"}],"version-history":[{"count":0,"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/posts\/32028\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/media\/4060"}],"wp:attachment":[{"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/media?parent=32028"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/categories?post=32028"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/tags?post=32028"},{"taxonomy":"aire-therapeutique","embeddable":true,"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/aire-therapeutique?post=32028"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}