{"id":34853,"date":"2024-05-24T08:19:39","date_gmt":"2024-05-24T08:19:39","guid":{"rendered":"https:\/\/www.etap-lab.com\/?p=14853"},"modified":"2026-04-17T18:27:59","modified_gmt":"2026-04-17T16:27:59","slug":"first-fluorescencefriday-the-word-of-our-expert","status":"publish","type":"post","link":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/first-fluorescencefriday-the-word-of-our-expert\/","title":{"rendered":"First #fluorescencefriday &#8211; the word of our expert"},"content":{"rendered":"<p>\ud83d\udd2c We wanted to share with you one of our cell image that shows <strong>primary cortical rat neurons<\/strong> (DIV14) stained for PSD-95 (<span style=\"color: #339966;\">synapses<\/span>) in green, MAP2 (<span style=\"color: #ff0000;\">dendrites<\/span>) in red and DAPI (<span style=\"color: #00ccff;\">nuclei<\/span>) in blue. Each little green dot shows an <span style=\"color: #3366ff;\">active synapse happening between two neurons<\/span>!<\/p>\n<p>\ud83e\udde0Ahmad Allouche, one of our <em>in vitro<\/em> expert, explains:<br \/>\n<em>&#8220;About the <strong>synaptic degeneration mechanism<\/strong>, it occurs early in neurodegenerative diseases and correlates with cognitive decline. Increased levels of synaptic proteins have been detected in the CSF in the <strong>early stages of Alzheimer\u2019s diseases (AD)<\/strong> presumably due to release from degenerating synapses.<br \/>\nPostsynaptic density protein 95 (PSD-95, also known as SAP-90 or DLG4) is a scaffolding protein participating in the organization and regulation of synapses. It binds to NMDA and AMPA receptors, potassium channels, and associated signalling proteins resulting in their clustering during the formation and maintenance of dendritic spines. The dysregulation of PSD-95 expression has been associated with neurodegenerative disorders. <\/em><\/p>\n<p><em>Reduced expression of PSD-95 has been observed in brain tissue from AD subjects and in mouse models of AD, making it <strong>an attractive target<\/strong> for <strong>developing strategies able to monitor PSD-95 accurately for therapeutics and diagnostics.<\/strong>&#8220;<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong><span style=\"color: #3366ff;\">Get in touch to develop your own study with our in vitro or in vivo models !<\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>Image was acquired with Operetta\u00ae CLS\u2122 High-Content Imaging System \/ REVVITY. Original picture \u00a9 ETAP-Lab 2024.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover First #fluorescencefriday &#8211; the word of our expert: \ud83d\udd2c We wanted to share with you one of our cell image that shows primary cortical rat neurons (DIV14) stained for PSD-95 (\u2026<\/p>\n","protected":false},"author":13,"featured_media":36896,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[207],"tags":[],"aire-therapeutique":[],"class_list":["post-34853","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-innovation"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>First #fluorescencefriday - the word of our expert - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"...primary cortical rat neurons (DIV14) stained for PSD-95 (synapses) in green, MAP2 (dendrites) in red and DAPI (nuclei) in blue. 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