{"id":49,"date":"2017-04-06T11:45:16","date_gmt":"2017-04-06T09:45:16","guid":{"rendered":"https:\/\/www.syncrosome.com\/?p=49"},"modified":"2026-04-17T17:51:08","modified_gmt":"2026-04-17T15:51:08","slug":"meta-analysis-of-mesenchymal-stem-cells-in-preclinical-parkinson-models","status":"publish","type":"post","link":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/meta-analysis-of-mesenchymal-stem-cells-in-preclinical-parkinson-models\/","title":{"rendered":"Meta analysis of mesenchymal stem cells in preclinical Parkinson models"},"content":{"rendered":"<p>Multiple studies have been performed to evaluate the effects of mesenchymal stem cells (MSCs) in preclinical Parkinson models.<\/p>\n<p>We performed a meta-analysis to estimate the treatment effect of unmodified MSCs on behavioral outcomes in preclinical studies of Parkinson&#8217;s disease (PD). We performed a systematic literature search to identify studies that used behavioral testing to evaluate the treatment effect of unmodified MSCs in PD models. Meta-analysis was used to determine pooled effect size for rotational behavior and limb function and meta-regression was performed to explore sources of heterogeneity.<\/p>\n<p>Twenty-five studies including three delivery routes, a wide range of doses, and multiple PD models were examined. Significant improvement was seen in the pooled standardized mean difference (SMD) for both rotational behavior (SMD: 1.24, 95% CI: 0.84,1.64) and limb function (SMD: 0.84, 95% CI: 0.01, 1.66). Using meta-regression, IV administration and higher dose had a larger effect on limb function. Treatment with MSCs improves behavioral outcomes in PD models.<\/p>\n<p>Our analyses suggest that MSCs could be considered for early stage clinical trials in the treatment of PD.<\/p>\n<p>About the article:<br \/>\nRiecke Jenny, Johns Katherine M., Cai Chunyan, Vahidy Farhaan Shaheer, Parsha Kaushik, Furr-Stimming Erin, Schiess Mya, and Savitz Sean I.. Stem Cells and Development. September 15, 2015, 24(18): 2082-2090. doi:10.1089\/scd.2015.0127.<\/p>\n<p>About Syncrosome:<br \/>\nSyncrosome is a scientific preclinical CRO based in France focused on validating animal disease models to assess the efficacy of new compounds in the field of CNS, Cardiovascular, Gastrointestinal and Respiratory diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover Meta analysis of mesenchymal stem cells in preclinical Parkinson models: Multiple studies have been performed to evaluate the effects of mesenchymal stem cells (MSCs) in\u2026<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[207],"tags":[],"aire-therapeutique":[229],"class_list":["post-49","post","type-post","status-publish","format-standard","hentry","category-science-and-innovation","aire-therapeutique-neurologie-cns"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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