{"id":51,"date":"2015-11-26T16:48:08","date_gmt":"2015-11-26T15:48:08","guid":{"rendered":"https:\/\/www.syncrosome.com\/?p=51"},"modified":"2026-04-17T17:51:12","modified_gmt":"2026-04-17T15:51:12","slug":"alpha-synuclein-in-parkinson-disease","status":"publish","type":"post","link":"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/alpha-synuclein-in-parkinson-disease\/","title":{"rendered":"Alpha-synuclein in Parkinson disease"},"content":{"rendered":"

Alpha Synuclein Parkinson:
\nFormation and accumulation of misfolded protein aggregates are a central hallmark of several neurodegenerative diseases. In Parkinson\u2019s disease (PD), the aggregation-prone protein alpha-synuclein (\u03b1-syn) is the culprit. In the past few years, another piece of the puzzle has been added with data suggesting that \u03b1-syn may self-propagate, thereby contributing to the progression and extension of PD. Of particular importance, it was the seminal observation of Lewy bodies (LB), a histopathological signature of PD, in grafted fetal dopaminergic neurons in the striatum of PD patients. Consequently, these findings were a conceptual breakthrough, generating the \u201chost to graft transmission\u201d hypothesis, also called the \u201cprion-like hypothesis.\u201d Several in vitro and in vivo studies suggest that \u03b1-syn can undergo a toxic templated conformational change, spread from cell to cell and from region to region, and initiate the formation of \u201cLB\u2013like aggregates,\u201d contributing to the PD pathogenesis. Here, we will review and discuss the current knowledge for such a putative mechanism on the prion-like nature of \u03b1-syn, and discuss about the proper use of the term prion-like.<\/p>\n

About the Article:
\nRecasens A and Dehay B (2014) Alpha-synuclein spreading in Parkinson\u2019s disease. Front. Neuroanat. 8:159.<\/p>\n

About Syncrosome:
\nSyncrosome is a scientific preclinical CRO based in France focused on validating animal disease models to assess the efficacy of new compounds in the field of CNS, Cardiovascular, Gastrointestinal and Respiratory diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"

Discover Alpha-synuclein in Parkinson disease: Alpha Synuclein Parkinson: Formation and accumulation of misfolded protein aggregates are a central hallmark of several neurodegenerative\u2026<\/p>\n","protected":false},"author":13,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[207],"tags":[],"aire-therapeutique":[229],"class_list":["post-51","post","type-post","status-publish","format-standard","hentry","category-science-and-innovation","aire-therapeutique-neurologie-cns"],"acf":[],"yoast_head":"\nAlpha-synuclein in Parkinson disease - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Discover Alpha-synuclein in Parkinson disease: Alpha Synuclein Parkinson: Formation and accumulation of misfolded protein aggregates are a central hallmark of several neurodegenerative\u2026\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.etap-lab.com\/en\/science-and-innovation\/alpha-synuclein-in-parkinson-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alpha-synuclein in Parkinson disease - 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