{"id":36277,"date":"2013-07-01T19:01:21","date_gmt":"2013-07-01T19:01:21","guid":{"rendered":"https:\/\/www.etap-lab.com\/?p=9876"},"modified":"2026-04-15T22:47:52","modified_gmt":"2026-04-15T20:47:52","slug":"oral-administration-of-d-limonene-controls-inflammation-in-rat-colitis-and-displays-anti-inflammatory-properties-as-diet-supplementation-in-humans","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/oral-administration-of-d-limonene-controls-inflammation-in-rat-colitis-and-displays-anti-inflammatory-properties-as-diet-supplementation-in-humans\/","title":{"rendered":"Oral administration of d-limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">AIMS:<\/h4>\n\n\n\n<p>To further explore the anti-inflammatory properties of d-Limonene.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">MAIN METHODS:<\/h4>\n\n\n\n<p>A rat model was used to compare evolution of TNBS (2,5,6-trinitrobenzene sulfonic acid)-induced colitis after oral feeding with d-Limonene compared to ibuprofen. Peripheral levels of TNF-\u03b1 (Tumor Necrosis Factor alpha) were assessed in all animals. Cell cultures of fibroblasts and enterocytes were used to test the effect of d-Limonene respectively on TNF\u03b1-induced NF-\u03baB (nuclear factor-kappa B) translocation and epithelial resistance. Finally, plasmatic inflammatory markers were examined in an observational study of diet supplementation with d-Limonene-containing orange peel extract (OPE) in humans.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">KEY FINDINGS:<\/h4>\n\n\n\n<p>Administered per os at a dose of 10mg\/kg p.o., d-Limonene induced a significant reduction of intestinal inflammatory scores, comparable to that induced by ibuprofen. Moreover, d-Limonene-fed rats had significantly lowered serum concentrations of TNF-\u03b1 compared to untreated TNBS-colitis rats. The anti-inflammatory effect of d-Limonene also involved inhibition of TNF\u03b1-induced NF-\u03baB translocation in fibroblast cultures. The application of d-Limonene on colonic HT-29\/B6 cell monolayers increased epithelial resistance. Finally, inflammatory markers, especially peripheral IL-6, markedly decreased upon OPE supplementation of elderly healthy subjects submitted or not to 56 days of dietary supplementation with OPE.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SIGNIFICANCE:<\/h4>\n\n\n\n<p>In conclusion, d-Limonene indeed demonstrates significant anti-inflammatory effects both in vivo and in vitro. Protective effects on the epithelial barrier and decreased cytokines are involved, suggesting a beneficial role of d-Limonene as diet supplement in reducing inflammation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover Oral administration of d-limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans: AIMS: To further explore the\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[235],"marque-de-ressource":[],"class_list":["post-36277","ressource","type-ressource","status-publish","hentry","categorie-de-ressource-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Oral administration of d-limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Discover Oral administration of d-limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans: AIMS: To further explore the\u2026\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.etap-lab.com\/en\/ressource\/oral-administration-of-d-limonene-controls-inflammation-in-rat-colitis-and-displays-anti-inflammatory-properties-as-diet-supplementation-in-humans\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Oral administration of d-limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans - 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