{"id":36278,"date":"2014-10-15T19:02:11","date_gmt":"2014-10-15T19:02:11","guid":{"rendered":"https:\/\/www.etap-lab.com\/?p=9878"},"modified":"2026-04-15T22:48:03","modified_gmt":"2026-04-15T20:48:03","slug":"anti-stress-effects-of-d-limonene-and-its-metabolite-perillyl-alcohol","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/anti-stress-effects-of-d-limonene-and-its-metabolite-perillyl-alcohol\/","title":{"rendered":"Anti-stress effects of d-Limonene and its metabolite perillyl alcohol"},"content":{"rendered":"

Stress is closely linked by its biological mechanisms to inflammation and by its consequences to accelerated aging. Stress triggers a hormonal response along the hypothalamus-pituitary-adrenal (HPA) axis, liable to disrupt the ortho \/ parasympathetic balance essential for a harmonious life. Proper nutrition and adequate physical activity, by limiting the harmful influence of stress, play important roles to avoid developing disease and to promote healthy aging. d-Limonene, a monoterpene shown to reduce inflammatory parameters in several pre-clinical and clinical models, could also develop an anti-stress action by altering ortho \/ parasympathetic parameters as well as central neurotransmitter functions. Here we report on a rat model, where a functional observational battery (FOB) was performed, submitting animals to non-pathological stress. d-Limonene or its metabolite perillyl alcohol (POH) were administered per os at a dose of 10mg\/kg. FOB tests were performed one hour before gavage then at 60, 120 and 180 minutes. These tests confirmed the stressed status of control rats fed vehicle. Conversely, a series of parameters were significantly less disturbed in treated rats who retained a better activity and displayed less sings of stress. These effects were more pronounced and sustained after ingestion of d-Limonene than POH, suggesting the role of endogeneous metabolization of the terpene. These studies show that d-Limonene exerts, through its metabolite POH, a significant anti-stress action measurable by behavioral and physiologic parameters under the influence of the nervous system. In addition to its anti-inflammatory effects, a beneficial role for d-Limonene as diet supplement could thus be claimed as an anti-stress substance.<\/p>\n","protected":false},"excerpt":{"rendered":"

Discover Anti-stress effects of d-Limonene and its metabolite perillyl alcohol: Stress is closely linked by its biological mechanisms to inflammation and by its consequences to\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[235],"marque-de-ressource":[],"class_list":["post-36278","ressource","type-ressource","status-publish","hentry","categorie-de-ressource-publications"],"acf":[],"yoast_head":"\nAnti-stress effects of d-Limonene and its metabolite perillyl alcohol - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Discover Anti-stress effects of d-Limonene and its metabolite perillyl alcohol: Stress is closely linked by its biological mechanisms to inflammation and by its consequences to\u2026\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.etap-lab.com\/en\/ressource\/anti-stress-effects-of-d-limonene-and-its-metabolite-perillyl-alcohol\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Anti-stress effects of d-Limonene and its metabolite perillyl alcohol - 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