{"id":36307,"date":"2006-11-01T19:24:09","date_gmt":"2006-11-01T19:24:09","guid":{"rendered":"https:\/\/www.etap-lab.com\/?p=9936"},"modified":"2026-04-15T22:55:18","modified_gmt":"2026-04-15T20:55:18","slug":"human-opiorphin-a-natural-antinociceptive-modulator-of-opioid-dependent-pathways","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/human-opiorphin-a-natural-antinociceptive-modulator-of-opioid-dependent-pathways\/","title":{"rendered":"Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways"},"content":{"rendered":"\n<p>Mammalian zinc ectopeptidases play important roles in turning off neural and hormonal peptide signals at the cell surface, notably those processing sensory information. We report here the discovery of a previously uncharacterized physiological inhibitor of enkephalin-inactivating zinc ectopeptidases in humans, which we have named Opiorphin. It is a QRFSR peptide that inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11), and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity in chemical and mechanical pain models by activating endogenous opioid-dependent transmission. Its function is closely related to the rat sialorphin peptide, which is an inhibitor of pain perception and acts by potentiating endogenous \u03bc- and \u03b4-opioid receptor-dependent enkephalinergic pathways. Here we demonstrate the functional specificity <em>in vivo<\/em>\u00a0of human Opiorphin. The pain-suppressive potency of Opiorphin is as effective as morphine in the behavioral rat model of acute mechanical pain, the pin-pain test. Thus, our discovery of Opiorphin is extremely exciting from a physiological point of view in the context of endogenous opioidergic pathways, notably in modulating mood-related states and pain sensation. Furthermore, because of its\u00a0<em>in vivo<\/em>\u00a0properties, Opiorphin may have therapeutic implications. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways: Mammalian zinc ectopeptidases play important roles in turning off neural and hormonal peptide\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[235],"marque-de-ressource":[],"class_list":["post-36307","ressource","type-ressource","status-publish","hentry","categorie-de-ressource-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Discover Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways: Mammalian zinc ectopeptidases play important roles in turning off neural and hormonal peptide\u2026\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.etap-lab.com\/en\/ressource\/human-opiorphin-a-natural-antinociceptive-modulator-of-opioid-dependent-pathways\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways - 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