{"id":36363,"date":"2021-11-15T10:15:44","date_gmt":"2021-11-15T10:15:44","guid":{"rendered":"https:\/\/www.etap-lab.com\/?p=13583"},"modified":"2026-10-13T15:10:25","modified_gmt":"2026-10-13T13:10:25","slug":"post-acute-delivery-of-%ce%b15-gabaa-antagonist-s-44819-improves-functional-recovery-in-juvenile-rats-following-stroke","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/post-acute-delivery-of-%ce%b15-gabaa-antagonist-s-44819-improves-functional-recovery-in-juvenile-rats-following-stroke\/","title":{"rendered":"Post-acute delivery of \u03b15-GABAA antagonist, S 44819, improves functional recovery in juvenile rats following stroke"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Consult this publication with Institut Servier &#8211; <strong>Post-acute delivery of \u03b15-GABAA antagonist, S 44819, improves functional recovery in juvenile rats following stroke<\/strong> &#8211; in which <em>in vivo<\/em> studies were conducted on our <a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vivo-models\/#subcat-211\">original model of transient ischemic stroke<\/a>, and demonstrating that targeting \u03b15-GABAA receptors improves neurological recovery after stroke in juvenile rats. Published in Experimental Neurology (2021).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-blue-light-color\"><strong class=\"sub-title\">Keywords:&nbsp;<\/strong>Animal model; Behavioural tests; GABA; Recovery; Stroke.<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Read the full article here:<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34597681\/\">Link of this publication to Pubmed<\/a> and <a href=\"https:\/\/doi.org\/10.1016\/j.expneurol.2021.113881\">https:\/\/doi.org\/10.1016\/j.expneurol.2021.113881<\/a><\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-primary\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.etap-lab.com\/en\/contact\/\">Contact an expert now<\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Authors<\/strong>: Florent Lebrun a b, Nicolas Violle a, Annelise Letourneur a, Christophe Muller a, Nicolas Fischer a, Anthony Levilly c, Cyrille Orset b c, Aurore Sors d, Denis Vivien b e<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Affiliates<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>a <strong>ETAP-Lab, STROK@LLIANCE<\/strong>, 13 Rue du Bois de la Champelle, 54500 Vandoeuvre-les-Nancy, France<\/li>\n\n\n\n<li>b <strong>Normandie Univ, UNICAEN, INSERM, GIP Cyceron, Institut Blood and Brain @Caen-Normandie (BB@C)<\/strong>, UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Caen, France<\/li>\n\n\n\n<li>c <strong>ESRP<\/strong> (European Stroke Research Platform), Centre Universitaire de Ressources Biologiques (CURB), Universit\u00e9 Caen Basse Normandie, Caen, France<\/li>\n\n\n\n<li>d <strong>Institut de Recherches Internationales Servier<\/strong>, Suresnes, France<\/li>\n\n\n\n<li>e <strong>Department of Clinical Research, CHU Caen-Normandie<\/strong>, Caen, France<\/li>\n<\/ul>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">Highlights<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The model of ischemia-reperfusion on adult rodent is transposable on 28 day-old rats<\/li>\n\n\n\n<li>\u03b15-GABAAR antagonist S 44819 improves middle-term neurological recovery after stroke in juvenile rats<\/li>\n\n\n\n<li>As in adult rodents, GABAergic system plays a key role in physiopathology of stroke in juvenile rodents<br><\/li>\n<\/ul>\n\n\n\n<div style=\"height:41px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-blue-light-color\">Abstract:<br><\/mark><\/em>Background and Objective<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">Evaluating \u03b15-GABAA Receptor Antagonism After Juvenile Stroke<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Hypo-excitability was reported in the peri-infarct tissue following stroke, an effect counteracted by a blockage of \u03b15-GABAA receptors in adult rodents. Our present study aims to evaluate the effect of a selective \u03b15-GABAA receptor antagonist, S 44819, in stroke in juvenile animals. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Experimental Model and Treatment Protocol<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">Development of a Juvenile Rat Model of Ischemic Stroke<br><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">We have set up and characterized <a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vivo-models\/#subcat-211\">an original model of transient ischemic stroke<\/a> in 28 day-old Sprague-Dawley rats (45-min occlusion of the middle cerebral artery by intraluminal suture). In this model, S 44819 (1, 3 and 10 mg\/kg, b.i.d) was orally administered from day 3 to day 16 after stroke onset. <a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/our-platforms\/#small-and-large-animal-facilities\">Sensorimotor recovery<\/a> was assessed on day 1, day 9 and day 16 after stroke onset. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Neurological Recovery Outcomes<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">S 44819 Improves Sensorimotor Recovery<br><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Results show that rats treated with S 44819 at the doses of 3 and 10 mg\/kg displayed a significant improvement of the neurological deficits (neuroscore) on day 9 and day 16, when compared with animals treated with vehicle. Grip-test data analysis reveals that rats treated with S 44819 at the dose of 3 mg\/kg displayed a better recovery on day 9 and day 16. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Conclusion<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">Targeting \u03b15-GABAA Receptors Enhances Post-Stroke Recovery<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">These results are in agreement with those previously observed in adult rats, demonstrating that targeting \u03b15-GABAA receptors improves neurological recovery after stroke in juvenile rats.<br><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Graphical abstract<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">Graphical description of preclinical stroke model of MCAO and sensorimotor recovery tests<\/h2>\n\n\n\n<figure class=\"wp-block-image size-medium is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"179\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2021\/11\/1-s2.0-S0014488621002892-ga1_lrg-publication-servier-illustration-300x179.jpg\" alt=\"Graphical abstract describing the preclinical protocol of MCAO\" class=\"wp-image-38398\" style=\"aspect-ratio:1.6761239633347882;width:300px;height:auto\" srcset=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2021\/11\/1-s2.0-S0014488621002892-ga1_lrg-publication-servier-illustration-300x179.jpg 300w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2021\/11\/1-s2.0-S0014488621002892-ga1_lrg-publication-servier-illustration-768x458.jpg 768w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2021\/11\/1-s2.0-S0014488621002892-ga1_lrg-publication-servier-illustration-1024x611.jpg 1024w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2021\/11\/1-s2.0-S0014488621002892-ga1_lrg-publication-servier-illustration.jpg 1485w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Discover Post-acute delivery of \u03b15-GABAA antagonist, S 44819, improves functional recovery in juvenile rats following stroke: Hypo-excitability was reported in the peri-infarct tissue\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[235],"marque-de-ressource":[242],"class_list":["post-36363","ressource","type-ressource","status-publish","hentry","categorie-de-ressource-publications","marque-de-ressource-strokalliance"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - 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