{"id":36372,"date":"2025-04-04T10:09:20","date_gmt":"2025-04-04T10:09:20","guid":{"rendered":"https:\/\/www.etap-lab.com\/?p=15310"},"modified":"2026-08-28T12:33:08","modified_gmt":"2026-08-28T10:33:08","slug":"poster-advancing-alzheimers-disease-models-for-preclinical-drug-testing","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/poster-advancing-alzheimers-disease-models-for-preclinical-drug-testing\/","title":{"rendered":"POSTER: &#8220;ADVANCING ALZHEIMER&#8217;S DISEASE MODELS FOR PRECLINICAL DRUG TESTING&#8221;"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Dr Ahmad Allouche<\/strong>, Head of <em>in vitro<\/em> biology, presented the team&#8217;s research* during <strong>AD\/PD 2025<\/strong> in Vienna in his poster &#8220;<strong>ADVANCING ALZHEIMER&#8217;S DISEASE MODELS FOR PRECLINICAL DRUG TESTING<\/strong>&#8220;.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Learn more about our cutting-edge platform for target identification &amp; drug discovery in the poster!<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-primary\"><a class=\"wp-block-button__link wp-element-button\" href=\"mailto:marketing@etap-lab.com?subject=Poster%20Request%20-%20ETAP-LAB%20-[muInterest]%20&amp;body=Hello%2C%20%0ACan%20you%20send%20me%20the%20poster%20dealing%20with%20[myInterest]%20\/%20[title]%20.%20Thank%20you.%20\">EASY POSTER REQUEST<\/a><\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Authors: <em>*Ahmad ALLOUCHE, Valentin TALLANDIER, Sonia KRIDI, L\u00e9ane DIER, Julie COLIN, Nicolas VIOLLE<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Affiliates:<em> ETAP-Lab, 54500, Vand\u0153uvre-l\u00e8s-Nancy, France<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract<\/strong>: <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Though Alzheimer&#8217;s disease (AD) is the most common cause of dementia, complete disease-modifying treatments are yet to be fully attained. The development and commercialization of new drugs is a lengthy and very expensive process and current approaches targeting the too-late stages of AD have had no consistent clinical benefit. For this reason, development of predictive and robust preclinical models, recapitulating early neuropathological features of AD are of urgent need. Here, we report the progress in our development of high throughput in vitro models that captures AD characteristics using physiopathologically relevant culture conditions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Assessment of cellular phenotypic changes (neurons or glial cells from rodent or human induced pluripotent stem cells (iPSCs) induced after an exposure of human amyloid oligomers (A\u03b2O and TauO) were performed using 2D-cultures, brain-on-chip (BoC) models, and a high content imaging system. These oligomeric preparations were prepared in-house from human A\u03b2<sub>1-42 <\/sub>and Tau (2N4R) monomers and were well-characterized by various methods (SDS-page, dot-blot, 8-Anilino-1-NaphthaleneSulfonic acid (ANS) and Sedimentation Velocity Analytical Ultracentrifugation (SV-AUC) assays).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Our data showed that increasing concentrations of oligomers have been associated with significantly loss of synaptic markers, reduction of neurite outgrowth and ultimately neuron death. They also triggered neuroinflammatory processes <em>via<\/em> activation of astrocytes. Induced neurodegeneration and neuroinflammation were successfully attenuated by pharmacologic compounds, including monoclonal antibodies, which have produced encouraging therapeutic results in clinical trials.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In conclusion, we characterized many experimental situations to better understand the mechanisms underlying AD, and targeting oligomers or their harmful effects which should give rise to new therapeutic interventions. Complexifying of in vitro models, combining neuron and glia, using BoC devices and targeting both amyloid and tau for development next generation AD prevention could be of great interest.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover POSTER: &#8220;ADVANCING ALZHEIMER&#8217;S DISEASE MODELS FOR PRECLINICAL DRUG TESTING&#8221;: Dr Ahmad Allouche , Head of in vitro biology, presented the team&#8217;s research* during AD\/PD 2025 in\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[236],"marque-de-ressource":[240],"class_list":["post-36372","ressource","type-ressource","status-publish","hentry","categorie-de-ressource-posters","marque-de-ressource-brainxplore"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>POSTER: &quot;ADVANCING ALZHEIMER&#039;S DISEASE MODELS FOR PRECLINICAL DRUG TESTING&quot; - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Discover POSTER: &quot;ADVANCING ALZHEIMER&#039;S DISEASE MODELS FOR PRECLINICAL DRUG TESTING&quot;: Dr Ahmad Allouche , Head of in vitro biology, presented the team&#039;s research* during AD\/PD 2025 in\u2026\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.etap-lab.com\/en\/ressource\/poster-advancing-alzheimers-disease-models-for-preclinical-drug-testing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"POSTER: &quot;ADVANCING ALZHEIMER&#039;S DISEASE MODELS FOR PRECLINICAL DRUG TESTING&quot; - 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