{"id":36805,"date":"2007-04-01T19:24:43","date_gmt":"2007-04-01T19:24:43","guid":{"rendered":"https:\/\/www.etap-lab.com\/?p=9938"},"modified":"2026-04-15T22:51:46","modified_gmt":"2026-04-15T20:51:46","slug":"structural-and-functional-recovery-elicited-by-combined-putrescine-and-aminoguanidine-treatment-after-aspirative-lesion-of-the-%ef%ac%81mbria-fornix-and-overlying-cortex-in-the-adult-rat","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/structural-and-functional-recovery-elicited-by-combined-putrescine-and-aminoguanidine-treatment-after-aspirative-lesion-of-the-%ef%ac%81mbria-fornix-and-overlying-cortex-in-the-adult-rat\/","title":{"rendered":"Structural and functional recovery elicited by combined putrescine and aminoguanidine treatment after aspirative lesion of the \ufb01mbria\u2013fornix and overlying cortex in the adult Rat"},"content":{"rendered":"\n<p>Damage to the adult CNS often causes permanent deficits. Based on a lesion model of septohippocampal pathway aspiration in the rat, we attempted to promote neuronal cell survival and post-traumatic recovery by using a pharmacological treatment combining aminoguanidine and putrescine (AGP). The functional recovery was followed over 15 weeks before morphological analysis. AGP treatment produced a persistent attenuation (approximately 50%) of the lesion-induced hyperactivity, a reduction (approximately 60%) in the sensorimotor impairments and an improved performance in the water-maze task which did not, however, rely upon improved memory capabilities. AGP weakened the lesion-induced decrease in ChAT-positive neurons in the medial septum and the extent of thalamic retrograde necrosis (by approximately 30% in each case) and resulted in a partial cholinergic reinnervation of the dentate gyrus. These promising results support the idea that coadministration of putrescine and aminoguanidine might become a potent way to foster structural and functional recovery (or compensation) in the adult mammalian CNS after injury. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover Structural and functional recovery elicited by combined putrescine and aminoguanidine treatment after aspirative lesion of the \ufb01mbria\u2013fornix and overlying cortex in the adult\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[235],"marque-de-ressource":[],"class_list":["post-36805","ressource","type-ressource","status-publish","hentry","categorie-de-ressource-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Structural and functional recovery elicited by combined putrescine and aminoguanidine treatment after aspirative lesion of the \ufb01mbria\u2013fornix and overlying cortex in the adult Rat - 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