{"id":36813,"date":"2004-12-01T19:30:52","date_gmt":"2004-12-01T19:30:52","guid":{"rendered":"https:\/\/www.etap-lab.com\/?p=9956"},"modified":"2026-04-15T22:54:51","modified_gmt":"2026-04-15T20:54:51","slug":"the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\/","title":{"rendered":"The endogenous androgen-regulated sialorphin modulates male rat sexual behavior"},"content":{"rendered":"\n

In sexually mature male rats, sialorphin is synthesized under androgenic control and its surge endocrine secretion is evoked in response to environmental acute stress. These findings led us to suggest that this signaling mediator might play a role in physiological and behavioral integration, especially reproduction. The present study investigates the effects induced by sialorphin on the male sexual behavior pattern. Intact male rats were treated in acute mode, with sialorphin at the 0.3, 1, and 3 microg\/kg doses, before being paired with receptive female for 45 min. The data obtained show that sialorphin increased, in a dose-related manner, the occurrence of intromissions across the successive ejaculatory sequences. The rats treated with the highest 3 microg\/kg dose significantly ejaculated less often compared to controls; however, 80% of them achieved up to three ejaculations. Further analyses of mount bouts for rats achieving three ejaculations reveal that there were significant stimulatory effects of sialorphin, at all doses, on the frequency of intromissions before ejaculation and on the propensity of males to engage in investigatory behavior directed to the female during the post-ejaculatory interval. Thus, sialorphin has the ability to modulate, at doses related to physiological circulating levels, the male rat mating pattern, that is, exerting a dual facilitative or inhibitory dose-dependent effect on the sexual performance, while stimulating the apparent sexual arousal or motivation. These findings led us to speculate that the endogenous androgen-regulated sialorphin helps modulate the adaptative balance between excitatory and inhibitory mechanisms serving appropriate male rat sexual response, depending on the context. <\/p>\n","protected":false},"excerpt":{"rendered":"

Discover The endogenous androgen-regulated sialorphin modulates male rat sexual behavior: In sexually mature male rats, sialorphin is synthesized under androgenic control and its surge\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[235],"marque-de-ressource":[],"class_list":["post-36813","ressource","type-ressource","status-publish","hentry","categorie-de-ressource-publications"],"acf":[],"yoast_head":"\nThe endogenous androgen-regulated sialorphin modulates male rat sexual behavior - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Discover The endogenous androgen-regulated sialorphin modulates male rat sexual behavior: In sexually mature male rats, sialorphin is synthesized under androgenic control and its surge\u2026\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.etap-lab.com\/en\/ressource\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The endogenous androgen-regulated sialorphin modulates male rat sexual behavior - ETAP-LAB\" \/>\n<meta property=\"og:description\" content=\"Discover The endogenous androgen-regulated sialorphin modulates male rat sexual behavior: In sexually mature male rats, sialorphin is synthesized under androgenic control and its surge\u2026\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.etap-lab.com\/en\/ressource\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\/\" \/>\n<meta property=\"og:site_name\" content=\"ETAP-LAB\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-15T20:54:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/04\/OpenGraph-defaut-Etap-Lab-3.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1800\" \/>\n\t<meta property=\"og:image:height\" content=\"1200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\\\/\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\\\/\",\"name\":\"The endogenous androgen-regulated sialorphin modulates male rat sexual behavior - ETAP-LAB\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#website\"},\"datePublished\":\"2004-12-01T19:30:52+00:00\",\"dateModified\":\"2026-04-15T20:54:51+00:00\",\"description\":\"Discover The endogenous androgen-regulated sialorphin modulates male rat sexual behavior: In sexually mature male rats, sialorphin is synthesized under androgenic control and its surge\u2026\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Ressources\",\"item\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressources\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Publications\",\"item\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/categorie-de-ressource\\\/publications\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"The endogenous androgen-regulated sialorphin modulates male rat sexual behavior\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/\",\"name\":\"Etap Lab\",\"description\":\"CRO Services\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#organization\",\"name\":\"Etap Lab\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/etap-lab-etap-lab-preclinical-cro-right-full-color-rgb-1920px-w-72ppi.png\",\"contentUrl\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/etap-lab-etap-lab-preclinical-cro-right-full-color-rgb-1920px-w-72ppi.png\",\"width\":550,\"height\":550,\"caption\":\"Etap Lab\"},\"image\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.linkedin.com\\\/company\\\/etap-lab\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The endogenous androgen-regulated sialorphin modulates male rat sexual behavior - ETAP-LAB","description":"Discover The endogenous androgen-regulated sialorphin modulates male rat sexual behavior: In sexually mature male rats, sialorphin is synthesized under androgenic control and its surge\u2026","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.etap-lab.com\/en\/ressource\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\/","og_locale":"en_US","og_type":"article","og_title":"The endogenous androgen-regulated sialorphin modulates male rat sexual behavior - ETAP-LAB","og_description":"Discover The endogenous androgen-regulated sialorphin modulates male rat sexual behavior: In sexually mature male rats, sialorphin is synthesized under androgenic control and its surge\u2026","og_url":"https:\/\/www.etap-lab.com\/en\/ressource\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\/","og_site_name":"ETAP-LAB","article_modified_time":"2026-04-15T20:54:51+00:00","og_image":[{"width":1800,"height":1200,"url":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/04\/OpenGraph-defaut-Etap-Lab-3.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.etap-lab.com\/en\/ressource\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\/","url":"https:\/\/www.etap-lab.com\/en\/ressource\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\/","name":"The endogenous androgen-regulated sialorphin modulates male rat sexual behavior - ETAP-LAB","isPartOf":{"@id":"https:\/\/www.etap-lab.com\/en\/#website"},"datePublished":"2004-12-01T19:30:52+00:00","dateModified":"2026-04-15T20:54:51+00:00","description":"Discover The endogenous androgen-regulated sialorphin modulates male rat sexual behavior: In sexually mature male rats, sialorphin is synthesized under androgenic control and its surge\u2026","breadcrumb":{"@id":"https:\/\/www.etap-lab.com\/en\/ressource\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.etap-lab.com\/en\/ressource\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.etap-lab.com\/en\/ressource\/the-endogenous-androgen-regulated-sialorphin-modulates-male-rat-sexual-behavior\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.etap-lab.com\/en\/"},{"@type":"ListItem","position":2,"name":"Ressources","item":"https:\/\/www.etap-lab.com\/en\/ressources\/"},{"@type":"ListItem","position":3,"name":"Publications","item":"https:\/\/www.etap-lab.com\/en\/categorie-de-ressource\/publications\/"},{"@type":"ListItem","position":4,"name":"The endogenous androgen-regulated sialorphin modulates male rat sexual behavior"}]},{"@type":"WebSite","@id":"https:\/\/www.etap-lab.com\/en\/#website","url":"https:\/\/www.etap-lab.com\/en\/","name":"Etap Lab","description":"CRO Services","publisher":{"@id":"https:\/\/www.etap-lab.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.etap-lab.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.etap-lab.com\/en\/#organization","name":"Etap Lab","url":"https:\/\/www.etap-lab.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.etap-lab.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/etap-lab-etap-lab-preclinical-cro-right-full-color-rgb-1920px-w-72ppi.png","contentUrl":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/etap-lab-etap-lab-preclinical-cro-right-full-color-rgb-1920px-w-72ppi.png","width":550,"height":550,"caption":"Etap Lab"},"image":{"@id":"https:\/\/www.etap-lab.com\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.linkedin.com\/company\/etap-lab\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/ressource\/36813","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/ressource"}],"about":[{"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/types\/ressource"}],"wp:attachment":[{"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/media?parent=36813"}],"wp:term":[{"taxonomy":"categorie-de-ressource","embeddable":true,"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/categorie-de-ressource?post=36813"},{"taxonomy":"marque-de-ressource","embeddable":true,"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/marque-de-ressource?post=36813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}