{"id":36818,"date":"2019-06-25T17:40:00","date_gmt":"2019-06-25T15:40:00","guid":{"rendered":"https:\/\/supazena.ovh\/c\/etap\/?post_type=ressource&#038;p=36639"},"modified":"2026-04-15T22:48:52","modified_gmt":"2026-04-15T20:48:52","slug":"etap-cell-a-new-in-vitro-pharmacology-service-for-drug-research-in-neurodegenerative-diseases","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/etap-cell-a-new-in-vitro-pharmacology-service-for-drug-research-in-neurodegenerative-diseases\/","title":{"rendered":"ETAP-Cell: a new in vitro pharmacology service for drug research in neurodegenerative diseases \u2013 Newsletter #5"},"content":{"rendered":"\n<p>The <strong>ETAP-Cell <\/strong>project continues to make progress as per the expected timeline. The whole team is delighted to announce that the <em>in vitro <\/em>laboratory is now fully equipped and already producing its first results!<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/ETAP-Cell-Lab.jpg\" alt=\"ETAP-Cell Lab\"\/><\/figure>\n\n\n\n<p>In late January, <a href=\"https:\/\/www.etap-lab.com\"><strong>ETAP-Lab<\/strong><\/a> created <strong>ETAP-Cell<\/strong>, a new <em>in vitro<\/em> pharmacological service in the field of evaluating proteopathic neurodegenerative diseases using our unique know-how in the solubilization and stabilization of oligomeric proteins (A\u03b2O, \u03b1SO and TauO).<\/p>\n\n\n\n<p>Three weeks ago, <strong>we successfully produced our first batch of soluble A\u03b2 oligomers<\/strong>. This preparation contains a mixture of stable dimers, trimers and tetramers of human A\u03b2 <sub>1-42<\/sub>, as well as some remaining monomeric forms of the peptides (Fig. 1).<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/SDS-PAGE-A-beta-oligomers.png\" alt=\"Characterization of ETAP-Cell\u2019s A\u03b2O preparation by SDS-PAGE \/ Coomassie staining.\" width=\"836\" height=\"419\"><\/p>\n\n\n\n<p>&nbsp;A\u03b2O-induced neurotoxicity was evaluated in cultured rat cortical neurons by MTT cell viability assay. As expected, ETAP-Cell\u2019s A\u03b2O preparation induced a clear dose-dependent neurotoxicity. Neurotoxic effects were increased in a time dependent manner and attenuated by brain-derived neurotrophic factor (BDNF), used as a positive control (Fig. 2).<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Human-A-beta-oligomers-toxicity.png\" alt=\"Human A\u03b2O-induced dose-dependent neurodegeneration. Colours: Strong: 24h; mild: 48h; light: 72h after A\u03b2O challenge. Data are expressed as percent of vehicle\" width=\"849\" height=\"544\"><\/p>\n\n\n\n<p>The coming weeks will be devoted to full validation of the A\u03b2O, \u03b1SO and TauO <em>in vitro<\/em> models, using 3 independent replicas for each model to ensure batch-to-batch reproducibility (new batch of each neurotoxin \/ replica). <em>In vitro<\/em> services will be available for sale from August.<\/p>\n\n\n\n<p><strong>Alongside this, ETAP-Lab will begin validation of the corresponding <em>in vivo <\/em>models in mice.<\/strong><\/p>\n\n\n\n<p>The ETAP-Lab team is very open to hearing about your needs and expectations, the better to integrate these into the solutions being developed over the next few months.<\/p>\n\n\n\n<p>Please do not hesitate to contact us, should you have any questions or suggestions.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.etap-lab.com\/contact-us\/\">Contact us<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Discover ETAP-Cell: a new in vitro pharmacology service for drug research in neurodegenerative diseases \u2013 Newsletter #5: The ETAP-Cell project continues to make progress as per the\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[238],"marque-de-ressource":[],"class_list":["post-36818","ressource","type-ressource","status-publish","hentry","categorie-de-ressource-technical-notes"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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