{"id":36829,"date":"2021-05-21T17:52:00","date_gmt":"2021-05-21T15:52:00","guid":{"rendered":"https:\/\/supazena.ovh\/c\/etap\/?post_type=ressource&#038;p=36658"},"modified":"2026-04-15T22:49:16","modified_gmt":"2026-04-15T20:49:16","slug":"newsletter-9-may-2021-etap-lab-launches-its-new-model-associating-beta-amyloid-oligomers-and-aged-mice","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-9-may-2021-etap-lab-launches-its-new-model-associating-beta-amyloid-oligomers-and-aged-mice\/","title":{"rendered":"Newsletter #9 : ETAP-Lab launches its new model, associating beta-amyloid oligomers and aged mice"},"content":{"rendered":"\n<p><strong>In May 2021, ETAP-Lab is adding its latest mouse model of Alzheimer\u2019s disease to its c<\/strong><strong>atalogue. <\/strong>Using our expertise in the manufacture of oligomers from <strong>A-beta<sub>1-42 <\/sub><\/strong>peptide, we&nbsp;&nbsp;have demonstrated that these compounds are toxic to the central nervous systems of <strong>aged mice <\/strong>and cause changes in the expression of <strong>synaptic markers <\/strong>and <strong>apoptotic signalling<\/strong>, associated with a decrease in their <strong>memory capacity<\/strong>.<\/p>\n\n\n\n<p>ETAP-Lab has been producing A-beta<sub>1-42 <\/sub>peptide oligomers since 2019, and offers an <em>in vitro<\/em> testing service for the screening of new therapeutic agents in neurodegenerative diseases (<a href=\"https:\/\/www.etap-lab.com\/neurodegenerative-diseases\/\">Find out more about our <em>in vitro <\/em>models &gt;&gt;<\/a>).<\/p>\n\n\n\n<p>We have now been able to show that intracerebroventricular administration of these same A-beta<sub>1-42<\/sub> oligomers (A\u03b2O) to 18-month-old mice leads to highly reproducible short- and long-term memory deficits (Fig. 1). These observed cognitive alterations are statistically correlated with decreased expression of synaptic markers (PSD-95) and increased apoptotic signalling (Bax\/Bcl2 ratio) in the hippocampus (Fig. 2). Used as a reference molecule, Donepezil significantly improved cognitive performance in these mice in both of the tests used (Fig.&nbsp; 3), confirming the model\u2019s translational value.<\/p>\n\n\n\n<figure class=\"wp-block-image\" id=\"attachment_12498\"><a href=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/fig-1-ABO-.jpg\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/fig-1-ABO-.jpg\" alt=\"\" class=\"wp-image-12498\"\/><\/a><figcaption class=\"wp-element-caption\">Fig 1: Deleterious effects on memory induced by the administration of ABO<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image\" id=\"attachment_12530\"><a href=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Figure-2-ABO.png\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Figure-2-ABO.png\" alt=\"Fig. 2: Donepezil beneficial effects on memory deficits induced by the administration of ABO\" class=\"wp-image-12530\"\/><\/a><figcaption class=\"wp-element-caption\">Fig. 2: Donepezil beneficial effects on memory deficits induced by the administration of ABO<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image\" id=\"attachment_12503\"><a href=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/fig-3-ABO.jpg\" target=\"_blank\" rel=\"noreferrer noopener\"><img decoding=\"async\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/fig-3-ABO.jpg\" alt=\"Eighteen days after the administration of A-beta 1-42 oligomers, ABO leads to significant disease of PSD-95 signal and significant increases of Bax\/Bcl-2 ratio.\" class=\"wp-image-12503\"\/><\/a><figcaption class=\"wp-element-caption\">Fig 3: Hippocampus protein analyses<\/figcaption><\/figure>\n\n\n\n<p>This research was carried out as part of the <a href=\"https:\/\/www.plantadvanced.com\/projets-collaboratifs\/bioprolor-2\">Bioprolor2<\/a> programme. Bioprolor2 is co-inanced by the \u201c<a href=\"https:\/\/www.grandest.fr\/\">Region Grand-Est<\/a>\u201d and the European Union through the \u201c<a href=\"https:\/\/www.europe-en-france.gouv.fr\/fr\/fonds-europeens\/fonds-europeen-de-developpement-regional-FEDER\">FEDER<\/a>-FSE Lorraine et Massif des Vosges 2014-2020\u201d operational programme.<\/p>\n\n\n\n<p>The A\u03b2O, together with the associated models now on offer from ETAP-Lab make it possible to evaluate both the efficacy and the therapeutic potential of molecules against Alzheimer\u2019s disease, both <em>in vitro <\/em>and <em>in vivo<\/em>.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.etap-lab.com\/contact-us\/\"><strong>For more information, please contact our team of neuroscientists &gt;&gt;<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover Newsletter #9 : ETAP-Lab launches its new model, associating beta-amyloid oligomers and aged mice: In May 2021, ETAP-Lab is adding its latest mouse model of Alzheimer\u2019s disease\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[238],"marque-de-ressource":[],"class_list":["post-36829","ressource","type-ressource","status-publish","hentry","categorie-de-ressource-technical-notes"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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