{"id":36831,"date":"2021-09-22T17:54:00","date_gmt":"2021-09-22T15:54:00","guid":{"rendered":"https:\/\/supazena.ovh\/c\/etap\/?post_type=ressource&#038;p=36660"},"modified":"2026-04-15T22:49:20","modified_gmt":"2026-04-15T20:49:20","slug":"newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/","title":{"rendered":"Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models"},"content":{"rendered":"\n<p>We&#8217;d like to take the opportunity, on World Alzheimer&#8217;s Day, to revisit the models ETAP-Lab makes available to the scientific community for use in the search for new therapies to fight this disease.<\/p>\n\n\n\n<figure class=\"wp-block-image alignleft\"><img decoding=\"async\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Mouse-maze-.jpg\" alt=\"\" class=\"wp-image-13534\"\/><\/figure>\n\n\n\n<p>Building on strong neurosurgery and behavioural analysis expertise, ETAP-Lab has developed a new model of Alzheimer&#8217;s disease, using human beta-amyloid peptide oligomers (hABO). Derived from a unique know-how, hABOs induce reproducible memory deficits in the elderly mouse, correlated with alterations in neurobiological markers characteristic of AD. In comparison with young mice, aged mice show increased susceptibility to the neurotoxic effects of hABO. This model is a new translational tool for preclinical pharmacology.<\/p>\n\n\n\n<p>&gt;&gt; <a href=\"https:\/\/www.etap-lab.com\/newsletter\/newsletter-9-may-2021-etap-lab-launches-its-new-model-associating-beta-amyloid-oligomers-and-aged-mice\/\" target=\"_blank\" rel=\"noreferrer noopener\">Read more about our in vivo model<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image alignleft\"><img decoding=\"async\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/in-vitro-culture.jpg\" alt=\"\" class=\"wp-image-13536\"\/><\/figure>\n\n\n\n<p>We&#8217;ve been working on developing <strong>new preclinical models <\/strong>&nbsp;for several years now, focusing on <strong>new<\/strong><strong><br>concepts<\/strong> such as hABO neurotoxicity and tau proteins. Our cellular models have allowed us to evaluate the efficacy of neuroprotective compounds and immunotherapy.<\/p>\n\n\n\n<p>&gt;&gt; <a href=\"https:\/\/www.etap-lab.com\/neurodegenerative-diseases\/\" target=\"_blank\" rel=\"noreferrer noopener\">Read more about our in vitro models<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image alignleft\"><img decoding=\"async\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/ABO-microfluidics.jpeg\" alt=\"\" class=\"wp-image-13367\"\/><\/figure>\n\n\n\n<p>In partnership with Netri (Lyon, France), a company specialised in the manufacture of microfluidic devices, we were able to demonstrate that our oligomers, used in non-cytotoxic doses, strongly disrupted electrical activity and connectivity (MEA technology)<\/p>\n\n\n\n<p>within neuronal networks in culture. This approach is an initial step towards an Alzheimer&#8217;s disease model that is both more physiological and more representative.<\/p>\n\n\n\n<p><a href=\"http:\/\/eepurl.com\/hDVbyn\" target=\"_blank\" rel=\"noreferrer noopener\">&gt;&gt; Download the application note<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image alignleft\"><img decoding=\"async\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/poster-image-AAIC-1.png\" alt=\"\" class=\"wp-image-13389\"\/><\/figure>\n\n\n\n<p><em>The results of our in vitro and in vivo work were presented at the last<\/em> AAIC conference:<br>\u201cNew Alzheimer models for drug screening based on improved human amyloid beta (1-42) oligomer preparations\u201d<\/p>\n\n\n\n<p><a href=\"http:\/\/eepurl.com\/g990Xn\" target=\"_blank\" rel=\"noreferrer noopener\">&gt;&gt;&nbsp;Download the poster<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image alignleft\"><img decoding=\"async\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/bioprolor2-GrandEst-et-FEDER.png\" alt=\"\" class=\"wp-image-13540\"\/><\/figure>\n\n\n\n<p>ETAP-Lab is also a partner in the <a href=\"https:\/\/www.etap-lab.com\/neurology\/#bioprolor\" target=\"_blank\" rel=\"noreferrer noopener\">Bioprolor2<\/a> research programme, co-financed by the ERDF and the Grand Est Region, as leader of the Alzheimer working group. This programme has allowed us to both develop new experimental models and identify and select new therapeutic compounds produced by French biotech company PAT (Nancy).<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>ETAP-Lab&#8217;s core mission is to support the development of new therapeutics for the benefit of human and animal health.<\/p>\n<\/blockquote>\n\n\n\n<p>Our team of experts care deeply about their work, and are available to answer any questions you may have.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-a89b3969 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.etap-lab.com\/contact-us\/\">Contact us<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Discover Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models: We&#8217;d like to take the opportunity, on World Alzheimer&#8217;s Day, to revisit the models ETAP-Lab\u2026<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[238],"marque-de-ressource":[],"class_list":["post-36831","ressource","type-ressource","status-publish","hentry","categorie-de-ressource-technical-notes"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Discover Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models: We&#039;d like to take the opportunity, on World Alzheimer&#039;s Day, to revisit the models ETAP-Lab\u2026\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models - ETAP-LAB\" \/>\n<meta property=\"og:description\" content=\"Discover Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models: We&#039;d like to take the opportunity, on World Alzheimer&#039;s Day, to revisit the models ETAP-Lab\u2026\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/\" \/>\n<meta property=\"og:site_name\" content=\"ETAP-LAB\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-15T20:49:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Mouse-maze-.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\\\/\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\\\/\",\"name\":\"Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models - ETAP-LAB\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2020\\\/12\\\/Mouse-maze-.jpg\",\"datePublished\":\"2021-09-22T15:54:00+00:00\",\"dateModified\":\"2026-04-15T20:49:20+00:00\",\"description\":\"Discover Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models: We'd like to take the opportunity, on World Alzheimer's Day, to revisit the models ETAP-Lab\u2026\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2020\\\/12\\\/Mouse-maze-.jpg\",\"contentUrl\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2020\\\/12\\\/Mouse-maze-.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Ressources\",\"item\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressources\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Technical notes\",\"item\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/categorie-de-ressource\\\/technical-notes\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/\",\"name\":\"Etap Lab\",\"description\":\"CRO Services\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#organization\",\"name\":\"Etap Lab\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/etap-lab-etap-lab-preclinical-cro-right-full-color-rgb-1920px-w-72ppi.png\",\"contentUrl\":\"https:\\\/\\\/www.etap-lab.com\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/etap-lab-etap-lab-preclinical-cro-right-full-color-rgb-1920px-w-72ppi.png\",\"width\":550,\"height\":550,\"caption\":\"Etap Lab\"},\"image\":{\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.linkedin.com\\\/company\\\/etap-lab\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models - ETAP-LAB","description":"Discover Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models: We'd like to take the opportunity, on World Alzheimer's Day, to revisit the models ETAP-Lab\u2026","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/","og_locale":"en_US","og_type":"article","og_title":"Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models - ETAP-LAB","og_description":"Discover Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models: We'd like to take the opportunity, on World Alzheimer's Day, to revisit the models ETAP-Lab\u2026","og_url":"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/","og_site_name":"ETAP-LAB","article_modified_time":"2026-04-15T20:49:20+00:00","og_image":[{"url":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Mouse-maze-.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/","url":"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/","name":"Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models - ETAP-LAB","isPartOf":{"@id":"https:\/\/www.etap-lab.com\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/#primaryimage"},"image":{"@id":"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/#primaryimage"},"thumbnailUrl":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Mouse-maze-.jpg","datePublished":"2021-09-22T15:54:00+00:00","dateModified":"2026-04-15T20:49:20+00:00","description":"Discover Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models: We'd like to take the opportunity, on World Alzheimer's Day, to revisit the models ETAP-Lab\u2026","breadcrumb":{"@id":"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/#primaryimage","url":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Mouse-maze-.jpg","contentUrl":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2020\/12\/Mouse-maze-.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.etap-lab.com\/en\/ressource\/newsletter-11-world-alzheimers-day-review-of-the-etap-lab-preclinical-models\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.etap-lab.com\/en\/"},{"@type":"ListItem","position":2,"name":"Ressources","item":"https:\/\/www.etap-lab.com\/en\/ressources\/"},{"@type":"ListItem","position":3,"name":"Technical notes","item":"https:\/\/www.etap-lab.com\/en\/categorie-de-ressource\/technical-notes\/"},{"@type":"ListItem","position":4,"name":"Newsletter #11: World Alzheimer\u2019s Day: review of the ETAP-Lab preclinical models"}]},{"@type":"WebSite","@id":"https:\/\/www.etap-lab.com\/en\/#website","url":"https:\/\/www.etap-lab.com\/en\/","name":"Etap Lab","description":"CRO Services","publisher":{"@id":"https:\/\/www.etap-lab.com\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.etap-lab.com\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.etap-lab.com\/en\/#organization","name":"Etap Lab","url":"https:\/\/www.etap-lab.com\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.etap-lab.com\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/etap-lab-etap-lab-preclinical-cro-right-full-color-rgb-1920px-w-72ppi.png","contentUrl":"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/03\/etap-lab-etap-lab-preclinical-cro-right-full-color-rgb-1920px-w-72ppi.png","width":550,"height":550,"caption":"Etap Lab"},"image":{"@id":"https:\/\/www.etap-lab.com\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.linkedin.com\/company\/etap-lab\/"]}]}},"_links":{"self":[{"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/ressource\/36831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/ressource"}],"about":[{"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/types\/ressource"}],"wp:attachment":[{"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/media?parent=36831"}],"wp:term":[{"taxonomy":"categorie-de-ressource","embeddable":true,"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/categorie-de-ressource?post=36831"},{"taxonomy":"marque-de-ressource","embeddable":true,"href":"https:\/\/www.etap-lab.com\/en\/wp-json\/wp\/v2\/marque-de-ressource?post=36831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}