{"id":38070,"date":"2015-10-30T10:04:00","date_gmt":"2015-10-30T09:04:00","guid":{"rendered":"https:\/\/www.etap-lab.com\/?post_type=ressource&#038;p=38070"},"modified":"2026-05-13T10:14:09","modified_gmt":"2026-05-13T08:14:09","slug":"publication-temporal-hemodynamic-and-histological-changes-rat-model-sugen-induced-pah","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/publication-temporal-hemodynamic-and-histological-changes-rat-model-sugen-induced-pah\/","title":{"rendered":"Publication: &#8220;Temporal hemodynamic and histological changes in a rat model sugen-induced PAH.&#8221;"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Research publication titled: &#8220;Temporal hemodynamic and histological changes in a rat model sugen-induced PAH.&#8221; V. Girod et al. SYNCROSOME. <strong>European Respiratory Journal 2015 46(suppl 59)<\/strong>: PA4910<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Read the full study here\/DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1183\/13993003.congress-2015.PA4910\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1183\/13993003.congress-2015.PA4910<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Authors: <\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vincent Girod, Audrey Bourdet, Sandra Robelet, Adeline Bouzereau, Delphine Revy<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Affiliations :<\/strong> In Vivo Pharmacology, SYNCROSOME, Marseille, France<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract<\/strong><br>Pulmonary arterial hypertension (PAH) is a progressive fatal disease characterized by a vascular remodeling of small pulmonary arteries leading to an increased right ventricular (RV) pressure and ultimately to RV failure. Treatments currently available do not cure the disease and new therapeutic strategies are needed. This involves the use of relevant animal models<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"d1425208e136\">The sugen (Su) model combines the administration of a vascular endothelial growth factor receptor blocker to a sequential exposure to hypoxia (Hx) and normoxia (Nx). Unlike the monocrotaline and hypoxia-induced PAH models, animals exposed to SuHxNx develop severe PAH with complex pulmonary vascular changes. However, very little data is available regarding temporal evolution of the disease, especially the appearance of plexiform lesions. The present work aimed at characterizing the progression of the disease over time using different approaches.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"d1425208e138\">Rats were treated with Su, exposed to Hx and maintained in Nx up to 10 weeks. RV pressure and hypertrophy were then measured and histological analysis of small pulmonary arteries was performed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"d1425208e140\">As expected, treatment with Su associated with an exposure to Hx+Nx worsened Hx-induced PAH (RVSP&gt;70 mmHg) with severe medial hypertrophy and intimal proliferation. The extent of vascular remodeling increased with the duration of Nx to reach a maximum after 3 weeks with 50% of the analysed vessels partially or totally occluded. Finally, plexiform lesions occurred immediately after the end of Hx and affected 35% of the small pulmonary arteries after 3 weeks of Nx. Death also occurred after 5 weeks.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Exposure to Su+Hx with 3 weeks of Nx could provide a relevant model for the development of new treatments for PAH.<\/p>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover Exciting research publication from our cardiology lab SYNCROSOME as co-author: Cardiovascular diseases (CVDs) are the leading cause of global mortality.<\/p>\n","protected":false},"featured_media":37803,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[235],"marque-de-ressource":[243],"class_list":["post-38070","ressource","type-ressource","status-publish","has-post-thumbnail","hentry","categorie-de-ressource-publications","marque-de-ressource-syncrosome"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Publication: &quot;Temporal hemodynamic and histological changes in a rat model sugen-induced PAH.&quot; - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Discover Exciting research publication from our cardiology lab SYNCROSOME as co-author: Cardiovascular diseases (CVDs) are the leading cause of global mortality.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.etap-lab.com\/en\/ressource\/publication-temporal-hemodynamic-and-histological-changes-rat-model-sugen-induced-pah\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publication: &quot;Temporal hemodynamic and histological changes in a rat model sugen-induced PAH.&quot; - ETAP-LAB\" \/>\n<meta property=\"og:description\" content=\"Discover Exciting research publication from our cardiology lab SYNCROSOME as co-author: Cardiovascular diseases (CVDs) are the leading cause of global mortality.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.etap-lab.com\/en\/ressource\/publication-temporal-hemodynamic-and-histological-changes-rat-model-sugen-induced-pah\/\" \/>\n<meta property=\"og:site_name\" content=\"ETAP-LAB\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-13T08:14:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/04\/Illustration-generique-news-science-v1-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/publication-temporal-hemodynamic-and-histological-changes-rat-model-sugen-induced-pah\\\/\",\"url\":\"https:\\\/\\\/www.etap-lab.com\\\/en\\\/ressource\\\/publication-temporal-hemodynamic-and-histological-changes-rat-model-sugen-induced-pah\\\/\",\"name\":\"Publication: \\\"Temporal hemodynamic and histological changes in a rat model sugen-induced PAH.\\\" - 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