{"id":38071,"date":"2019-03-21T10:14:00","date_gmt":"2019-03-21T09:14:00","guid":{"rendered":"https:\/\/www.etap-lab.com\/?post_type=ressource&#038;p=38071"},"modified":"2026-05-13T10:20:42","modified_gmt":"2026-05-13T08:20:42","slug":"publication-soproterenol-induced-heart-failure-in-rat-heart-evaluation-and-cardioprotective-strategy","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/publication-soproterenol-induced-heart-failure-in-rat-heart-evaluation-and-cardioprotective-strategy\/","title":{"rendered":"Publication: &#8220;Isoproterenol-induced heart failure in rat heart: evaluation and cardioprotective strategy.&#8221;"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Research publication titled: &#8220;Isoproterenol-induced heart failure in rat heart: evaluation and cardioprotective strategy.&#8221; G. Bourdier, et al. SYNCROSOME. Presented during <strong>Printemps de la Cardiologie 2019. Cardiovascular Diseases Supplements Volume 11, Issue 2, April 2019, Page 230<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Read the full study here\/DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.acvdsp.2019.02.107\" target=\"_blank\" rel=\"noreferrer noopener\"><a href=\"https:\/\/doi.org\/10.1016\/j.acvdsp.2019.02.107\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1016\/j.acvdsp.2019.02.107<\/a><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Authors: <\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">G. Bourdier, S Robelet, <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Affiliations :<\/strong> SYNCROSOME, Luminy biotech entreprises, Marseille, France<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract<\/strong><br><strong><em>Introduction<\/em><\/strong><br>It is well established that cardiac remodelling plays a pivotal role in the development of heart failure (HF), a leading cause of death worldwide. Meanwhile, a preclinical rat model of isoproterenol (Iso)-induced HF causes sympathetic hyperactivity, an important factor of cardiac remodelling, hemodynamic changes and cardiac fibrosis development. Several studies showed that metoprolol, a \u03b21-adrenergic receptor (\u03b21-AR) blocker prevents cardiac dysfunction following prolonged \u03b2-AR stimulation in different preclinical models.<br><strong><em>Objective<\/em><\/strong><br>We evaluated the cardioprotective effects of metoprolol on cardiac remodelling and diastolic function in a severe Iso-induced HF model using echocardiography and cardiac pressure measurement.<br><strong><em>Method<\/em><\/strong><br>Rats received Iso injections (Iso; 5 mg\/kg\/day, N = 5), metoprolol (Meto; 24 mg\/kg\/day) + Iso 5 (Iso + Meto, N = 6), or vehicle (N = 9) for 7 days. Left ventricular (LV) dimensions and function were followed-up by echocardiography before and after the treatment to assess LV hypertrophy. After echocardiography, LV end-diastolic pressure (LVEDP) was recorded to assess ventricular compliance and rat hearts were used for cardiac remodelling analysis.<br><strong><em>Results<\/em><\/strong><br>One week of Iso injections significantly increased LVEDP (+ 48%) and was associated with a major LV hypertrophy, characterised by a significant increase in LV mass (+ 33%) and a thickening of the LV walls observed by echocardiography. Simultaneous treatment with metoprolol prevented diastolic dysfunction and LV remodelling. Hypertrophy and fibrosis will be analysed in each group by histology (on-going experiments).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br><strong><em>Conclusion<\/em><\/strong><br>Metoprolol afforded a cardioprotective effect on cardiac remodelling and diastolic dysfunction in Iso-induced HF model. Echocardiography and LVEDP measurements validate the reversibility of hypertrophic HF, and Iso-induced HF developed in rat could represent an effective and predictive preclinical model for evaluating antihypertrophic and antifibrotic agents.<\/p>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover Exciting research publication from our cardiology lab SYNCROSOME as co-author: Cardiovascular diseases (CVDs) are the leading cause of global mortality.<\/p>\n","protected":false},"featured_media":37803,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[235],"marque-de-ressource":[243],"class_list":["post-38071","ressource","type-ressource","status-publish","has-post-thumbnail","hentry","categorie-de-ressource-publications","marque-de-ressource-syncrosome"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Publication: &quot;Isoproterenol-induced heart failure in rat heart: evaluation and cardioprotective strategy.&quot; - 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