{"id":38072,"date":"2026-05-02T09:00:26","date_gmt":"2026-05-02T07:00:26","guid":{"rendered":"https:\/\/www.etap-lab.com\/?post_type=ressource&#038;p=38072"},"modified":"2026-05-13T11:27:12","modified_gmt":"2026-05-13T09:27:12","slug":"publication-aging-alters-the-vulnerability-pattern-to-amyloid-beta-oligomers-in-wild-type-mice-a-behavioral-and-neurobiological-study","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/publication-aging-alters-the-vulnerability-pattern-to-amyloid-beta-oligomers-in-wild-type-mice-a-behavioral-and-neurobiological-study\/","title":{"rendered":"Publication:  &#8220;Aging alters the vulnerability pattern to amyloid-beta oligomers in wild-type mice: a behavioral and neurobiological study&#8221;"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Publication on <strong>Aging alters the vulnerability pattern to amyloid-beta oligomers in wild-type mice: a behavioral and neurobiological study<\/strong>. Allouche, A., Colin, J., Birck, C. et al. Published in <strong>Alzheimer&#8217;s Research &amp; Therapy (2026).<\/strong> <\/p>\n\n\n\n<p>Read the full article: <a href=\"https:\/\/doi.org\/10.1186\/s13195-026-02051-2\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1186\/s13195-026-02051-2<\/a> <\/p>\n\n\n\n<p><strong>Authors<\/strong>: Ahmad Allouche 1, Julie Colin 1, Catherine Birck 2, Henri Schroeder 3, Valentin Tallandier 1, Marion Baldoni 1, Christophe Muller 1, Mohamed Afrassi 1 &amp; Nicolas Violle 1<\/p>\n\n\n\n<p><strong>Affiliated<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>1 ETAP-Lab, 54500 Vandoeuvre-l\u00e8s-Nancy, France<\/li>\n\n\n\n<li>2 Plateforme de Biologie Structurale Int\u00e9gr\u00e9e, CBI-IGBMC, CNRS UMR 7104, Inserm U1258, University of Strasbourg, 67400 Illkirch, France<\/li>\n\n\n\n<li>3 UMR Inserm 1256 nGERE \u2013 Lorraine University, 9 Avenue de La For\u00eat de Haye, 54500 Vandoeuvre-L\u00e8s-Nancy, France<\/li>\n<\/ul>\n\n\n\n<p><strong>Abstract:<\/strong><\/p>\n\n\n\n<p><strong><em>Background<\/em><\/strong><br>Aging is the primary risk factor for sporadic Alzheimer\u2019s disease (AD). While amyloid-beta oligomers (A\u03b2Os) accumulation is a key neuropathological process in AD, their specific effects in aged brains and how aging modulates brain response to A\u03b2Os remains poorly understood. We investigated how aging contributes to A\u03b2O-induced neurotoxicity and cognitive deficits in mice.<\/p>\n\n\n\n<p><strong><em>Methods<\/em><\/strong><br>After biochemical and in vitro characterizations on primary cultures of cortical neurons, A\u03b2Os or their vehicle were intracerebrally injected into both 3- and 18-month-old wild-type mice. A broad spectrum of assays including synaptic markers, neuroinflammation, apoptosis and cognitive functions was used to establish a preliminary characterization of the interplay between age and A\u03b2Os. In vivo data were analyzed using a multifactorial design (Treatment\u2009\u00d7\u2009Age), with two-way ANOVA or other appropriate statistical models.<\/p>\n\n\n\n<p><strong><em>Results<\/em><\/strong><br>Old mice had significantly reduced synaptic proteins SNAP-25 and PSD-95, elevated neuroinflammatory markers, and increased neuronal apoptosis in hippocampus and cortex, despite showing cognitive performances similar to young mice. All brain biomarkers were worsened after A\u03b2O injection in both young and old mice. Age and A\u03b2O effects either accumulated or interacted to promote neuroinflammation and apoptosis, depending on brain areas, whereas their effects on synaptic proteins were strictly additive. Moreover, A\u03b2O injection induced only mild spatial memory deficits in young mice, in contrast with those observed in old mice in both episodic and spatial memory tests.<\/p>\n\n\n\n<p><strong><em>Discussion<\/em><\/strong><br>Whereas the young brain showed resilience to maintain memory performances after A\u03b2O injection, the coping capacities of the aging brain were exceeded by A\u03b2O effects. At the neurobiological level, age and A\u03b2O effects were mainly additive, but also acted synergistically in a brain region-dependent vulnerability pattern. This study highlights the value of incorporating aging into preclinical models to improve their translational validity and enhance their relevance for drug testing targeting early stages of sporadic AD.<\/p>\n\n\n\n<p><em><strong>Keywords: <\/strong><\/em><strong>Aging, Alzheimer\u2019s disease, Amyloid-beta oligomers, Neurodegeneration, Neuroinflammation, Memory. <\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover Publication on Functional discrimination of CSF from Alzheimer\u2019s patients in a brain on chip platform: Publication : Functional discrimination of CSF from Alzheimer\u2019s patients\u2026<\/p>\n","protected":false},"featured_media":37803,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[235],"marque-de-ressource":[240],"class_list":["post-38072","ressource","type-ressource","status-publish","has-post-thumbnail","hentry","categorie-de-ressource-publications","marque-de-ressource-brainxplore"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Publication: &quot;Aging alters the vulnerability pattern to amyloid-beta oligomers in wild-type mice: a behavioral and neurobiological study&quot; - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Aging alters the vulnerability pattern to amyloid-beta oligomers in wild-type mice: a behavioral and neurobiological study. 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