{"id":38318,"date":"2026-08-28T12:01:34","date_gmt":"2026-08-28T10:01:34","guid":{"rendered":"https:\/\/www.etap-lab.com\/?post_type=ressource&#038;p=38318"},"modified":"2026-10-16T11:39:33","modified_gmt":"2026-10-16T09:39:33","slug":"poster-regenerative-and-immunocompatible-hesc-derived-skin-substitute-for-sickle-cell-leg-ulcers","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/poster-regenerative-and-immunocompatible-hesc-derived-skin-substitute-for-sickle-cell-leg-ulcers\/","title":{"rendered":"POSTER: Regenerative and Immunocompatible hESC-Derived Skin Substitute for Sickle Cell Leg Ulcers"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Discover the joint poster <strong>with I-STEM on &#8220;Regenerative and Immunocompatible hESC-Derived Skin Substitute for Sickle Cell Leg Ulcers<\/strong>&#8221; presented by Jean-Fran\u00e7ois Bisson at the European Tissue Repair Society (<a href=\"https:\/\/etrs2026.eu\/\">ETRS<\/a>) meeting in Rouen (France) in September 2026. Sickle cell leg ulcers remain a major unmet medical need, with limited therapeutic options and poor healing outcomes despite increasing patient numbers worldwide. The objective was to evaluate the engraftment efficiency of an Innovative Medicinal Product (IMP) <a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/dermatology\/in-vivo-models\/#cat-170\">in our original in vivo mice model<\/a> &#8211; with SKINAXIS being expert in regenerative medicine evaluation and a European leader in skin graft modeling. Preclinical studies demonstrated the IMP bioactivity, safety, stability, engraftment capacity, and immune compatibility, supporting its clinical development as a novel regenerative medicine approach for chronic wound management.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Significant milestones since the publication: <\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A first <a href=\"https:\/\/istem.eu\/en\/pace-2\/\" target=\"_blank\" rel=\"noreferrer noopener\">clinical trial is planned for early 2027 for I-Stem<\/a>.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-primary\"><a class=\"wp-block-button__link wp-element-button\" href=\"mailto:marketing@etap-lab.com?subject=Poster%20Request%20-%20ETAP-LAB%20-ESDR-Heidelberg-2026%20&amp;body=Hello%2C%20%0ACan%20you%20send%20me%20the%20poster%20dealing%20with%20Dermatology%20Research%20presented%20at%20ESDR-Heidelberg.%20Thank%20you.%20\">EASY POSTER REQUEST<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image alignright size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"213\" height=\"300\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/08\/Capture-Poster-skin-substitute-skin-leg-ulcers-I-STEM-SKINAXIS-ETRS-2026-213x300.png\" alt=\"Poster-skin-substitute-skin-leg-ulcers-I-STEM-SKINAXIS-ETRS-2026\" class=\"wp-image-38436\" srcset=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/08\/Capture-Poster-skin-substitute-skin-leg-ulcers-I-STEM-SKINAXIS-ETRS-2026-213x300.png 213w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/08\/Capture-Poster-skin-substitute-skin-leg-ulcers-I-STEM-SKINAXIS-ETRS-2026.png 363w\" sizes=\"auto, (max-width: 213px) 100vw, 213px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Authors<\/strong>: Sophie Domingues<sup>1,2<\/sup>, Annabelle Darle<sup>1,2<\/sup>, Houda Abla<sup>1,2<\/sup>, Imene Guiliano<sup>1,2<\/sup>, Jean-Fran\u00e7ois Bisson<sup>3<\/sup>, Sara Abbas<sup>1,2<\/sup>, Patricia Senet<sup>4<\/sup>, Marc Peschanski<sup>1,2<\/sup>, Christine Baldeschi<sup>1,5<\/sup><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Affiliations<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>1 Institut des cellules Souches pour le Traitement et l&#8217;\u00c9tude des maladies Monog\u00e9niques (I-STEM), 91100 Corbeil-Essonnes, France<\/li>\n\n\n\n<li>2 Centre d\u2019Etude des Cellules Souches, 91100 Corbeil-Essonnes, France<\/li>\n\n\n\n<li>3 ETAP-LAB, 54500 Vandoeuvre-l\u00e8s-Nancy, France<\/li>\n\n\n\n<li>4 AH-HP, Groupe hospitalier Sorbonne-Universit\u00e9, 75 970 Paris, France<\/li>\n\n\n\n<li>5 Universit\u00e9 Paris-Saclay, U861, 91100 Corbeil-Essonnes, France<\/li>\n<\/ul>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract<\/strong>:<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">Sickle Cell Leg Ulcers: An Unmet Need for Advanced Regenerative Therapies<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Sickle cell leg ulcers are chronic wounds that are difficult to heal and represent a major healthcare challenge due to limited treatments and increasing patient numbers. Novel tissue-based therapies are urgently needed. Advances in skin engineering have enabled substitutes manufactured under Good Manufacturing Practices (GMP) using adult stem cells such as keratinocytes. Human embryonic stem cells (hESC) also provide an unlimited source of differentiated cells for regenerative medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">Development of a GMP-Manufactured hESC-Derived Skin Substitute<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">We (I-Stem) developed an Innovative Medicinal Product (IMP) composed of hESC-derived keratinocytes seeded on fibrin matrix to reconstruct a skin substitute produced in a dedicated medical device for manufacturing, transport, and clinical application. The GMP protocol enabled robust large-scale production of keratinocytes from GMP-grade hESC. The fibrin scaffold was generated from viro-inactivated pooled human plasma free of anti-HLA antibodies. Quality controls ensured identity, purity, potency, genomic stability, and safety of the IMP.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">In Vitro Bioactivity and Wound Healing Potential<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In vitro, the IMP formed a homogeneous epidermal-like layer expressing keratinocyte markers without pluripotency markers. Conditioned medium from the IMP significantly accelerated wound closure compared with fibrin alone. Cytokine profiling revealed enrichment in factors involved in wound healing, angiogenesis, and tissue repair.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">In Vivo Engraftment, Stability and Therapeutic Performance<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In vivo, in nude mice, the IMP showed efficient engraftment and formed an epidermis expressing human markers, consistent with enhanced wound closure observed with conditioned medium versus fibrin alone. In addition, the product remained stable up to 96 hours after release, supporting its transport and clinical use.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">Immune Compatibility and Long-Term Safety Assessment<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In a humanized mouse model, the IMP showed no immune rejection and <a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/dermatology\/in-vivo-models\/#cat-170\">sustained graft survival,<\/a> whereas primary cell-based constructs showed rejection. Biodistribution and toxicology studies showed no cell dissemination or toxicity six months after grafting.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">A Promising hESC-Based Skin Substitute for Clinical Translation<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Overall, these data demonstrate that a GMP-manufactured hESC-derived skin substitute is functional, bioactive, safe, and immunologically compatible in vivo. A first clinical trial is planned for early 2027.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover the joint poster with I-STEM on &ldquo;Regenerative and Immunocompatible hESC-Derived Skin Substitute for Sickle Cell Leg Ulcers&rdquo; presented by Jean-Fran&ccedil;ois Bisson at the European Tissue Repair Society (ETRS) meeting in Rouen (France) in September 2026. Sickle cell leg ulcers remain a major unmet medical need, with limited therapeutic options and poor healing outcomes despite [&hellip;]<\/p>\n","protected":false},"featured_media":38150,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[236],"marque-de-ressource":[241],"class_list":["post-38318","ressource","type-ressource","status-publish","has-post-thumbnail","hentry","categorie-de-ressource-posters","marque-de-ressource-skinaxis"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>POSTER: Regenerative and Immunocompatible hESC-Derived Skin Substitute for Sickle Cell Leg Ulcers - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Discover the joint poster with I-STEM on &quot;Regenerative and Immunocompatible hESC-Derived Skin Substitute for Sickle Cell Leg Ulcers&quot; presented by\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.etap-lab.com\/en\/ressource\/poster-regenerative-and-immunocompatible-hesc-derived-skin-substitute-for-sickle-cell-leg-ulcers\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"POSTER: Regenerative and Immunocompatible hESC-Derived Skin Substitute for Sickle Cell Leg Ulcers - 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