{"id":38389,"date":"2026-02-04T09:00:00","date_gmt":"2026-02-04T08:00:00","guid":{"rendered":"https:\/\/www.etap-lab.com\/?post_type=ressource&#038;p=38389"},"modified":"2026-10-16T17:01:10","modified_gmt":"2026-10-16T15:01:10","slug":"poster-effects-of-protein-c-activator-ab002-in-a-ich-rat-model","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/poster-effects-of-protein-c-activator-ab002-in-a-ich-rat-model\/","title":{"rendered":"Poster: Effects of Protein C activator AB002 on hemorrhage and lesion volume in a rat model of collagenase-induced intracerebral hemorrhage"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Poster dealing with <strong>Effects of Protein C activator AB002 on hemorrhage and lesion volume in a rat model of collagenase-induced intracerebral hemorrhage<\/strong>. The objective was to evaluate whether AB002 impacts hemorrhage or lesion volume in our <a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vivo-models\/#cat-186\">rat model of ICH, in comparison to Tenecteplase (TNK)<\/a>. After preclinical studies conducted by our expert team, the poster concludes that AB002 maintains safety while preserving antithrombotic potential, without an increased bleeding risk. Norah G. Verbout et al. Poster presented at <strong>International Stroke Conference (ISC) by Aronora<\/strong> team (2026, New Orleans, USA). Poster also <a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/str.57.suppl_1.WP058\">published in Stroke 57(Suppl_1)<\/a>, February 2026. | DOI: 10.1161\/str.57.suppl_1.WP058. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-blue-light-color\"><em><strong>Keywords<\/strong><\/em>: Hemorrhagic stroke, collagenase-induced intracerebral hemorrhage, ICH, drug development<\/mark>, <mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-blue-light-color\">antithrombotic therapy, bleeding risk safety<\/mark><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>Authors<\/strong>: Norah G. Verbout1, Auriane Ma\u00efza 2, Annelise Letourner 2, Nicolas Violle 3, Denis Vivien 4, Christina Lorentz 1, Jeffrey L. Saver 5, Andr\u00e1s Gruber 6, Erik I. Tucker 1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Affiliated<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>1. <a href=\"https:\/\/www.aronora.com\/scientific-publications\/?program=ab002\">Aronora<\/a>, Portland, OR, USA<\/li>\n\n\n\n<li>2.ETAP-Lab \u2013Strok@alliance, Caen, France<\/li>\n\n\n\n<li>3. ETAP-Lab \u2013Strok@alliance, Nancy, France<\/li>\n\n\n\n<li>4. INSERM UMRS U1237 PhIND, Caen, France<\/li>\n\n\n\n<li>5. David Geffen Schoolof Medicine, Universityof California, Los Angeles, CA<\/li>\n\n\n\n<li>6. Work performed whileat Aronora. (retired), Portland, OR<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<figure class=\"wp-block-image alignright size-medium is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"181\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/10\/Capture-poster-Aronora-Strokalliance-2026-ICH-stroke-300x181.png\" alt=\"Capture-poster-Aronora-Strokalliance-2026-ICH-stroke\" class=\"wp-image-38390\" style=\"width:300px;height:auto\" srcset=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/10\/Capture-poster-Aronora-Strokalliance-2026-ICH-stroke-300x181.png 300w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/10\/Capture-poster-Aronora-Strokalliance-2026-ICH-stroke.png 611w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-primary\"><a class=\"wp-block-button__link wp-element-button\" href=\"mailto:marketing@etap-lab.com?subject=Poster%20Request%20-%20ETAP-LAB%20-[myInterest]%20&amp;body=Hello%2C%20%0ACan%20you%20send%20me%20the%20poster%20dealing%20with%20effects-of-protein-C-activator-AB002-stroke%20\/%20Strokalliance-2026%20.%20Thank%20you.%20\">Easy poster request<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-blue-light-color\">Abstract:<\/mark><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">The Need for Safer Thrombolytic Therapies in Acute Ischemic Stroke<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Hemorrhagic risks associated with fibrinolytic drugs limit their use to a subset of acute ischemic stroke (AIS) patients. A hemostatically safe, rapidly-acting antithrombotic\/thrombolytic may have broad patient eligibility and improve outcomes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">AB002 is a selective protein C activator enzyme under development for treating acute thrombotic emergencies. A proof-of-concept Phase 2 clinical study in patients with end-stage renal disease undergoing hemodialysis showed that AB002 significantly reduced dialyzer clotting without detectable hemostatic impairment (NCT03963895). In preclinical studies, AB002 reduces cerebral infarct volume in both rat and mouse stroke models and exerts potent antithrombotic\/thrombolytic effects in a non-human primate model of acute vascular graft thrombosis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Here, we evaluated whether AB002 affects hemorrhage or lesion volume in a rat model of collagenase-induced intracerebral hemorrhage (ICH), in comparison to vehicle or tenecteplase (TNK).<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\"><strong>Experimental Design and Methods<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Procedures were approved by the institutional animal care and use committee. Using adult male rats (~300 g), collagenase (0.5 IU in 1 \u00b5L sterile saline) was injected over 1 min into the right striatum to induce ICH. Rats first received AB002 (15 \u00b5g\/kg) or vehicle via the tail vein 15 min post-ICH, administered as bolus and infusion over 40 min. Immediately after, TNK (5 mg\/kg) or vehicle was administered via a separate tail vein as a rapid bolus, generating a combination of 4 groups (n = 18\/per). At 24 h post-ICH, neurological function was assessed using a 15-point scale. Rats then underwent MRI to acquire T2* (hemorrhage) and T2-weighted (lesion) images. Image analysis was performed using ImageJ by investigators blinded to treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\"><strong>AB002 Does Not Increase Hemorrhage or Lesion Volume<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">AB002 treatment did not significantly alter hemorrhage or lesion volumes compared to vehicle control, assessed by MRI. Compared to TNK treated rats, lesion and hemorrhage volumes in AB002 treated rats appeared to be lower (p = 0.06). Lastly, AB002 treatment prior to TNK did not significantly alter hemorrhage or lesion volumes compared to TNK alone. No differences were observed between groups in mortality, neuroscores, or body weight.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\"><strong>Implications for Stroke Treatment<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">AB002 did not worsen hemorrhage or lesion volume in a rat model of ICH and did not impair neurological outcomes. We conclude that administration of the protein C activator AB002 before TNK thrombolysis may be reasonably safe and offer a broad therapeutic benefit in AIS and other thrombotic emergencies without an increased bleeding risk.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"450\" height=\"156\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/10\/4394540.jpg\" alt=\"Effects of treatments on intracerebral hemorrhage volume and lesion volume.\" class=\"wp-image-38391\" srcset=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/10\/4394540.jpg 450w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/10\/4394540-300x104.jpg 300w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><figcaption class=\"wp-element-caption\">Figure 1. Effects of treatments on intracerebral hemorrhage volume and lesion volume. Twenty-four hours collagenase treatment, median intracerebral hemorrhage volumes and lesions were measured. Shown are medians with interquartile ranges. Individual data are plotted. Statistical analysis for effect of treatment was performed with a one-way ANOVA with Tukey\u2019s test for multiple comparisons.<\/figcaption><\/figure>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Aging alters the vulnerability pattern to amyloid-beta oligomers in wild-type mice: a behavioral and neurobiological study. By Allouche, A., Colin, J., Birck, C. et al. Alzheimer&#8217;s Research &#038; Therapy (2026).<\/p>\n","protected":false},"featured_media":38150,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[236],"marque-de-ressource":[242],"class_list":["post-38389","ressource","type-ressource","status-publish","has-post-thumbnail","hentry","categorie-de-ressource-posters","marque-de-ressource-strokalliance"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Poster: Effects of Protein C activator AB002 on hemorrhage and lesion volume in a rat model of collagenase-induced intracerebral hemorrhage - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Poster on Effects of Protein C activator AB002 on hemorrhage and lesion volume in a rat model of collagenase-induced intracerebral hemorrhage, in comparison to Tenecteplase (TNK), showing that AB002 maintains safety while preserving antithrombotic potential.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.etap-lab.com\/en\/ressource\/poster-effects-of-protein-c-activator-ab002-in-a-ich-rat-model\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Poster: Effects of Protein C activator AB002 on hemorrhage and lesion volume in a rat model of collagenase-induced intracerebral hemorrhage - 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