{"id":38440,"date":"2025-11-15T14:37:00","date_gmt":"2025-11-15T13:37:00","guid":{"rendered":"https:\/\/www.etap-lab.com\/?post_type=ressource&#038;p=38440"},"modified":"2026-10-16T16:54:08","modified_gmt":"2026-10-16T14:54:08","slug":"poster-translational-multi-model-platform-for-preclinical-evaluation-of-thrombolytics-in-a-i-stroke","status":"publish","type":"ressource","link":"https:\/\/www.etap-lab.com\/en\/ressource\/poster-translational-multi-model-platform-for-preclinical-evaluation-of-thrombolytics-in-a-i-stroke\/","title":{"rendered":"Poster: A Translational Multi Model Platform for Preclinical Evaluation of Thrombolytics in Acute Ischemic Stroke"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Discover the poster dealing with <strong>A Translational Multi Model Platform for Preclinical Evaluation of Thrombolytics in Acute Ischemic Stroke<\/strong>, presented by Annelise Letourneur, <strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-blue-light-color\">STROK@LLIANCE<\/mark><\/strong> team, at the Neuroscience congress (SfN) in San Diego (USA) in November 2025. The development of new thrombolytic treatments for ischemic stroke continues to face significant challenges in translating findings from preclinical studies to clinical efficacy. To improve the predictive value of preclinical evaluations, we have developed <strong>an innovative translational platform<\/strong> that combines <strong>several complementary experimental models of ischemic stroke<\/strong>, from <a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vitro-models\/#cat-179\"><em>in vitro<\/em> evaluation<\/a> to<em> <\/em><a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vivo-models\/#subcat-209\"><em>in vivo<\/em> evaluation<\/a> and safety. This approach allows us <strong>to analyze the efficacy, mechanisms of action, and safety of new therapeutic candidates under conditions that closely mimic clinical reality<\/strong>, particularly in patients with <strong><a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vivo-models\/#cat-186\">comorbidities<\/a><\/strong>. The poster presents the platforms, exemplified in 2 models through the evaluation of Microlyse\u00ae*, a von Willebrand factor\u2013targeted thrombolytic agent that activates plasminogen independently of fibrin. Preclinical studies conducted on the drug candidate was presented with TargED* kind permission.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Significant milestones since the poster presentation:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/targedbiopharmaceuticals.com\/?s=microlyse\" target=\"_blank\" rel=\"noreferrer noopener\">Microlyse<\/a>\u00ae, a new thrombolytic agent developed by TargED, currently in clinical development.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-blue-light-color\"><strong>Keywords<\/strong>: Thrombolytics, thrombolytic therapy, microlyse, drug development, Acute Ischemic Stroke, ischemic stroke, preclinical stroke models<\/mark><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>Authors<\/strong>: <strong>*A. LETOURNEUR<\/strong> 1, F. LEBRUN 1, H. LEBAS 1, M. BAGUENEAU 1, F. STROKALLIANCE 1, E. CLERGUE 1, N. VIOLLE 2, D. VIVIEN 3;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Affiliated<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>1. ETAP-Lab, CAEN, France;&nbsp;<\/li>\n\n\n\n<li>2. Neurol., ETAP-Lab, Vandoeuvre-l\u00e8s-Nancy, France;&nbsp;<\/li>\n\n\n\n<li>3. INSERM U1237 &#8211; Phind, CAEN, France<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<figure class=\"wp-block-image alignright size-medium is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"212\" src=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/10\/Capture-Poster-Thrombolytics-in-Acute-Ischemic-Stroke-Targed-Strokalliance-SfN-2025-300x212.png\" alt=\"illustration-Poster-Thrombolytics-in-Acute-Ischemic-Stroke-Targed-Strokalliance-SfN-2025\" class=\"wp-image-38441\" style=\"width:300px;height:auto\" srcset=\"https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/10\/Capture-Poster-Thrombolytics-in-Acute-Ischemic-Stroke-Targed-Strokalliance-SfN-2025-300x212.png 300w, https:\/\/www.etap-lab.com\/wp-content\/uploads\/2026\/10\/Capture-Poster-Thrombolytics-in-Acute-Ischemic-Stroke-Targed-Strokalliance-SfN-2025.png 513w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-primary\"><a class=\"wp-block-button__link wp-element-button\" href=\"mailto:marketing@etap-lab.com?subject=Poster%20Request%20-%20ETAP-LAB%20-[myInterest]%20&amp;body=Hello%2C%20%0ACan%20you%20send%20me%20the%20poster%20dealing%20with%20[myInterest]%20\/%20[title]%20.%20Thank%20you.%20\">Easy poster request<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-blue-light-color\">Abstract<\/mark><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-black-color\">:<\/mark><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\"><strong>Objective: <\/strong>Building a Predictive Preclinical Platform for Stroke Drug Development<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">We established a translational preclinical platform using complementary rodent models of ischemic stroke to assess new thrombolytic candidates, with rt-PA or tenecteplase (TNK) as clinical benchmarks. We then applied this workflow to evaluate Microlyse, a novel thrombolytic agent.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>Background<\/em><\/strong>: <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">Overcoming Translational Challenges in Ischemic Stroke Research<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Despite decades of research, drug development for ischemic stroke has been hindered by translational issues, leading to clinical failures. We report a series of studies aiming to create a robust and versatile workflow of innovative rodent models enabling precise investigation of drug efficacy, mechanism of action, interactions with gold-standard fibrinolytics, and risks of hemorrhagic transformation (HT) and cerebral bleeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">Methods: Multi-Model Preclinical Stroke Platform and Advanced Imaging Workflow<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">We developed a multi-model translational platform including:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 Two innovative and complementary <a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vivo-models\/#subcat-184\">mouse models of MCA occlusion inducing fibrin- or platelet-rich clots<\/a> with differential responses to thrombolytics<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 <a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vivo-models\/#subcat-184\">Inclusion of clinically relevant comorbidities (diabetes, hypertension)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022<a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/our-platforms\/#preclinical-medical-imaging\"> Translational and advanced imaging <\/a>(laser speckle, MRI) to assess recanalization, reperfusion, infarct volume, HT, BBB disruption, and endothelial activation<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 A novel neuroscore to monitor functional recovery over 5 weeks in rats<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 A refined <a href=\"https:\/\/www.etap-lab.com\/en\/cro-services\/neurovascular-stroke\/in-vivo-models\/#cat-186\">collagenase-induced ICH model to assess bleeding risks<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 rt-PA or TNK used as reference comparators<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">Results: Microlyse Demonstrates Efficacy Across Multiple Experimental Stroke Models<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Alteplase improved recanalization and reduced infarct size in fibrin-rich clots within a narrow time window. Like Alteplase, Microlyse reduced lesion volume and improved reperfusion. Platelet-rich clots showed resistance to rt-PA, mimicking poor responders. In this model, Microlyse\u2014unlike Alteplase\u2014reduced lesion volume, showing superior efficacy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In rats, both rt-PA and Microlyse improved neuroscore, correlating with lesion volume at 5 weeks.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In mice, comorbidities increased lesion size, HT, and neuroinflammation, while impairing fibrinolysis and enhancing rt-PA-related HT. In diabetic mice, Alteplase showed no benefit on lesion volume, while Microlyse remained effective, indicating broader applicability.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the collagenase model, TNK and some anticoagulants significantly increased bleeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-m-font-size\">Conclusion: A Translational Tool for Accelerating Stroke Therapy Development<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This multi-model platform offers a robust, translationally relevant tool for evaluating novel stroke therapies, enabling:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 Efficacy comparison with rt-PA or TNK<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 Simulation of high-risk or non-responder subpopulations<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u2022 Early detection of safety or interaction risks<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Integrated into a comprehensive workflow, these models have already supported development of several agents, including Microlyse, now advancing to clinical evaluation.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Discover the poster dealing with A Translational Multi Model Platform for Preclinical Evaluation of Thrombolytics in Acute Ischemic Stroke, presented by Annelise Letourneur, STROK@LLIANCE team, at the Neuroscience congress (SfN) in San Diego (USA) in November 2025. The development of new thrombolytic treatments for ischemic stroke continues to face significant challenges in translating findings from [&hellip;]<\/p>\n","protected":false},"featured_media":38150,"template":"","meta":{"_acf_changed":false},"categorie-de-ressource":[236],"marque-de-ressource":[242],"class_list":["post-38440","ressource","type-ressource","status-publish","has-post-thumbnail","hentry","categorie-de-ressource-posters","marque-de-ressource-strokalliance"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Poster: A Translational Multi Model Platform for Preclinical Evaluation of Thrombolytics in Acute Ischemic Stroke - ETAP-LAB<\/title>\n<meta name=\"description\" content=\"Translational ischemic stroke models for preclinical drug development, thrombolytic testing, efficacy assessment, safety evaluation, and advanced imaging. 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