ETAP will participate to NutrEvent 2015 on June 17 & 18 in Lille (France), represented by Pascale ROZAN and Jean-François BISSON
ETAP will participate on June 17 & 18 to NutrEvent in Lille. You can contact us for scheduling a meeting there with Pascale ROZAN or Jean-François BISSON . For more information about this meeting click here.
Inflammation adversely affects the health of millions of people worldwide, and there is an unmet medical need for better anti-inflammatory drugs. We evaluated the therapeutic interest of mycolactone, a polyketide-derived macrolide produced by Mycobacterium ulcerans. Bacterial production ofmycolactone in human skin causes a combination of ulcerative, analgesic, and anti-inflammatory effects. Whereas ulcer formation is mediated by the proapoptotic activity of mycolactone on skin cells via hyperactivation of Wiskott-Aldrich syndrome proteins, analgesia results from neuronal hyperpolarization via signaling through angiotensin II type 2 receptors. Mycolactone also blunts the capacity of immune