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in vitro & in vivo Neurology

Since its inception, ETAP-Lab has showcased robust consistently expertise in preclinical neurology, initially focusing on in vivo models and more recently expanding into in vitro approaches. We specialize particularly such as stroke, neurodegenerative diseases featuring Alzheimer’s and Parkinson’s models, as well as psychopharmacology and cognition.

Our rodent models by area of expertise

Ischemic stroke Models

Fibrin rich-clot thrombosis

Platelet-rich clot thrombosis

Permanent ischemia

Transient ischemia attack


Hemorrhagic Stroke Models

Intraparenchymal or intraventricular haemorrhages (heterologous blood)

Intracerebral hemorrhages induced by collagenase injection

Subarachnoid hemorrhages

In vitro models

Amyloid Beta Oligomers model (rodent and HiPS cells)

Tau Oligomers model

Alpha Synuclein oligomers model


In vivo models

Early Alzheimer’s diseases model with Amyloid Beta Oligomers and aged mice

Parkinson’s disease model induced with 6-OHDA


Elevated plus Maze

Defensive burying test

Light/Dark box test



Forced Swim Test

Sucrose preference Test



Morris Water Maze

Novel Object Recognition

Neuro-pharmacokinetic (Neuro-PK)

Biodistribution study

Our platform

Behavioural tests

Stereotaxic & micro-surgery


Histology & Immunohistochemistry

Biological assays

In vitro pharmacology

Our R&D Projects


The BIO-DIAMOND project stands as a pioneering pilot initiative showcasing the potential of organ-on-chip technology to expedite the market entry of drug candidates in the “discovery” and “pre-clinical” phases, specifically focusing on Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis (ALS).

The project, in collaboration with NETRI, has emerged as a winner of the “Innovations in biotherapies and bioproduction” call for projects funded by the French government as part of France 2030.


This collaborative project with Plant Advanced Technologies (PAT) and the IMoPA-CNRS laboratory at the University of Lorraine aims to discover new plant-derived anti-inflammatory compounds, with a special emphasis on bryophyte group plants.

Selected by the Grand Est Region and the State, this collaborative research initiative is backed by a total budget of 1.2 million euros.


STROKTURA, Stroke for the Future, aims to find innovative solutions in brain imaging applied to preclinical models of stroke, with the purpose of testing future therapies for ischemic strokes in humans. This project, led by our team of experts in collaboration with BB@C, with scientific and technical support from PhIND, ESR3P, and CYCERON, is financially supported by FEDER and the Normandy Region.