Stroke
Ischemic stroke Models
- Fibrin rich-clot thrombosis
- Platelet-rich clot thrombosis
- Permanent ischemia
- Transient ischemia attack
Hemorrhagic Stroke Models
- Intraparenchymal or intraventricular haemorrhages (heterologous blood)
- Intracerebral hemorrhages induced by collagenase injection
- Subarachnoid hemorrhages
Neurodegenerative Diseases
In vitro models
- Amyloid Beta Oligomers model (rodent and HiPS cells)
- Tau Oligomers model
- Alpha Synuclein oligomers model
In vivo models
- Early Alzheimer’s diseases model with Amyloid Beta Oligomers and aged mice
- Parkinson’s disease model induced with 6-OHDA
Psychopharmacology
Anxiety
- Elevated plus Maze
- Defensive burying test
- Light/Dark box test
Depression
- Forced Swim Test
- Sucrose preference Test
Learning
- Morris Water Maze
- Novel Object Recognition
Pharmacology
- Neuro-pharmacokinetic (Neuro-PK)
- Biodistribution study
Our platform
Behavioural tests
Stereotaxic & micro-surgery
Imaging
Histology & Immunohistochemistry
Biological assays
In vitro pharmacology
Our R&D Projects
Bio-Diamond
The BIO-DIAMOND project stands as a pioneering pilot initiative showcasing the potential of organ-on-chip technology to expedite the market entry of drug candidates in the “discovery” and “pre-clinical” phases, specifically focusing on Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis (ALS).
The project, in collaboration with NETRI, has garnered recognition and financial support through the government-funded “Innovations in Biotherapies and Bioproduction” call for proposals under the France 2030 framework.
BrioFlam
This collaborative project with Plant Advanced Technologies (PAT) and the IMoPA-CNRS laboratory at the University of Lorraine aims to discover new plant-derived anti-inflammatory compounds, with a special emphasis on bryophyte group plants.
Selected by the Grand Est Region and the State, this collaborative research initiative is backed by a total budget of 1.2 million euros.
STROKTURA
STROKTURA, Stroke for the Future, aims to find innovative solutions in brain imaging applied to preclinical models of stroke, with the purpose of testing future therapies for ischemic strokes in humans. This project, led by our team of experts in collaboration with BB@C, with scientific and technical support from PhIND, ESR3P, and CYCERON, is financially supported by FEDER and the Normandy Region.