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in vitro & in vivo Neurology

Since its inception, ETAP-Lab has showcased robust consistently expertise in preclinical neurology, initially focusing on in vivo models and more recently expanding into in vitro approaches. We specialize particularly such as stroke, neurodegenerative diseases featuring Alzheimer’s and Parkinson’s models, as well as psychopharmacology and cognition.

Our rodent models by area of expertise

Ischemic stroke Models

Fibrin rich-clot thrombosis

Platelet-rich clot thrombosis

Permanent ischemia

Transient ischemia attack

 

Hemorrhagic Stroke Models

Intraparenchymal or intraventricular haemorrhages (heterologous blood)

Intracerebral hemorrhages induced by collagenase injection

Subarachnoid hemorrhages

In vitro models

Amyloid Beta Oligomers model (rodent and HiPS cells)

Tau Oligomers model

Alpha Synuclein oligomers model

 

In vivo models

Early Alzheimer’s diseases model with Amyloid Beta Oligomers and aged mice

Parkinson’s disease model induced with 6-OHDA

Anxiety

Elevated plus Maze

Defensive burying test

Light/Dark box test

 

Depression 

Forced Swim Test

Sucrose preference Test

 

Learning

Morris Water Maze

Novel Object Recognition

Neuro-pharmacokinetic (Neuro-PK)

Biodistribution study

Our platform

Behavioural tests

Stereotaxic & micro-surgery

Imaging

Histology & Immunohistochemistry

Biological assays

In vitro pharmacology

Our R&D Projects

Bio-Diamond

The BIO-DIAMOND project stands as a pioneering pilot initiative showcasing the potential of organ-on-chip technology to expedite the market entry of drug candidates in the “discovery” and “pre-clinical” phases, specifically focusing on Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis (ALS).

The project, in collaboration with NETRI, has garnered recognition and financial support through the government-funded “Innovations in Biotherapies and Bioproduction” call for proposals under the France 2030 framework.

BrioFlam

This collaborative project with Plant Advanced Technologies (PAT) and the IMoPA-CNRS laboratory at the University of Lorraine aims to discover new plant-derived anti-inflammatory compounds, with a special emphasis on bryophyte group plants.

Selected by the Grand Est Region and the State, this collaborative research initiative is backed by a total budget of 1.2 million euros.

STROKTURA

STROKTURA, Stroke for the Future, aims to find innovative solutions in brain imaging applied to preclinical models of stroke, with the purpose of testing future therapies for ischemic strokes in humans. This project, led by our team of experts in collaboration with BB@C, with scientific and technical support from PhIND, ESR3P, and CYCERON, is financially supported by FEDER and the Normandy Region.