Preclinical in vitro & in vivo Neurology research services

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Stroke

Ischemic stroke Models

  • Fibrin rich-clot thrombosis
  • Platelet-rich clot thrombosis
  • Permanent ischemia
  • Transient ischemia attack

Hemorrhagic Stroke Models

  • Intraparenchymal or intraventricular haemorrhages (heterologous blood)
  • Intracerebral hemorrhages induced by collagenase injection
  • Subarachnoid hemorrhages

Neurodegenerative Diseases

In vitro models

  • Amyloid Beta Oligomers model (rodent and HiPS cells)
  • Tau Oligomers model
  • Alpha Synuclein oligomers model

In vivo models

  • Early Alzheimer’s diseases model with Amyloid Beta Oligomers and aged mice
  • Parkinson’s disease model induced with 6-OHDA

Continue on the STROKALLIANCE website

Psychopharmacology

Anxiety

  • Elevated plus Maze
  • Defensive burying test
  • Light/Dark box test

Depression 

  • Forced Swim Test
  • Sucrose preference Test

Learning

  • Morris Water Maze
  • Novel Object Recognition

Pharmacology

  • Neuro-pharmacokinetic (Neuro-PK)

 

  • Biodistribution study

Our platform

Behavioural tests

Stereotaxic & micro-surgery

Imaging

Histology & Immunohistochemistry

Biological assays

In vitro pharmacology

Our R&D Projects

Bio-Diamond

The BIO-DIAMOND project stands as a pioneering pilot initiative showcasing the potential of organ-on-chip technology to expedite the market entry of drug candidates in the “discovery” and “pre-clinical” phases, specifically focusing on Alzheimer’s, Parkinson’s, and Amyotrophic Lateral Sclerosis (ALS).

The project, in collaboration with NETRI, has garnered recognition and financial support through the government-funded “Innovations in Biotherapies and Bioproduction” call for proposals under the France 2030 framework.

BrioFlam

This collaborative project with Plant Advanced Technologies (PAT) and the IMoPA-CNRS laboratory at the University of Lorraine aims to discover new plant-derived anti-inflammatory compounds, with a special emphasis on bryophyte group plants.

Selected by the Grand Est Region and the State, this collaborative research initiative is backed by a total budget of 1.2 million euros.

STROKTURA

STROKTURA is propelling stroke research forward with its groundbreaking project, funded by FEDER. We are excited to announce the initiation of STROKTURA: Stroke for the Future. Co-financed by FEDER and the Normandy Region, our team of experts will spearhead this project in collaboration with BB@C, receiving scientific and technical support from PhIND, ESR3P, and CYCERON. The primary objective is to propose innovative solutions in brain imaging applied to preclinical models of strokes, with the aim of testing future therapies for ischemic strokes in humans.