PRECLINICAL CRO SERVICES
STROK@LLIANCE – Dedicated research Lab for Neurovascular diseases
We offer high-translational efficacy and safety models that integrate key risk factors in an industrial standards environment. Our services cover both in vitro and in vivo approaches, supported by a comprehensive portfolio that includes hemostasis assays, cerebral hemorrhage and stroke models, and advanced imaging technologies such as MRI, PET, and molecular imaging. Our fully equipped platforms for bioassays, histology, and immunohistochemistry enable in-depth analysis and biomarker profiling. We offer both standardized and customized solutions tailored to your specific needs in the field of neurovascular research and stroke.
Our models
in vitro Models
Rotational Thromboelastography (ROTEM) | Human whole blood
Clot lysis assay |Human blood
Excitotoxicity-induced cellular stress | Glutamate
MAIN READOUTS
Clot formation and lysis parameters | Lysis time | Cell viability | Neurite network | Synaptic density
in vivo Models in mice & rats
Distal Ischemic Stroke models
Thrombin model | Fibrin-rich clot thrombosis
FeCl3 or AlCl3 models | Platelet-rich clot thrombosis
Hemorrhagic transformation following ischemic stroke model (with a comorbidity)
Proximal Ischemic Stroke models
Thrombo-embolic stroke model | Multiclot version
Transient middle cerebral artery occlusion model (tMCAo)
Hemorrhagic Stroke models
Collagenase model | Vascular rupture
In situ infusion of heterologous blood or autologous blood | No vascular rupture
Intracerebral aneurysms
in vivo Models in pigs
Efficacy model: Hemorrhagic Stroke models | Collagenase model | Vascular rupture
Customized Stroke models available on other pathologies – On demand
MAIN READOUTS
Lesion, oedema & Hemorrhage quantifications | MCA recanalization | Molecular MRI | Behavioural tests | (Immuno)histology & bioassays on brain tissue, including hemoglobin dosage | Acute superficial tissue perfusion (CBF index)|Brain tissue perfusion | Neurovascular coupling following whisker stimulation | Blood brain barrier integrity.
Our platforms
Behavioural tests
Stereotaxic & micro-surgery
in vivo Imaging
Histology & Immunohistochemistry
Biological assays
In vitro pharmacology
R&D Project
STROKTURA
STROKTURA, Stroke for the Future, aims to find innovative solutions in brain imaging applied to preclinical models of stroke, with the purpose of testing future therapies for ischemic strokes in humans. This project, led by our team of experts in collaboration with BB@C, with scientific and technical support from PhIND, ESR3P, and CYCERON, is financially supported by FEDER and the Normandy Region.
