POSTER: “Pro-healing effects of Plasana One®, an argon-generated cold plasma on ischemic skin wounds”
J.-F. Bisson1 , L. Razafitrimo1 , L. Ogikian1 , R. Da Silva2,3 , P.-M. François3 , Y. Matton3 , A. Rousseau2 - 2025
Discover the excellent results on ischemic skin wounds in our Poster: “Pro-healing effects of Plasana One®, an argon-generated cold plasma on ischemic skin wounds”.
Presented by Jean-François Bisson at the European Society for Dermatological Research (ESDR 2025, Antwerp, Belgium), featuring results from a client study on our ischemic skin wound model, conducted in collaboration with École Polytechnique, Laboratoire de Physique des Plasmas & Plasana Médical.
💡This study contributed to the preclinical development of the Plasana One® technology, an innovative device which is now entering clinical trials, designed to efficiently treat chronic wounds such as venous leg ulcers and diabetic foot ulcers.
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Authors: J.-F. Bisson1 , L. Razafitrimo1 , L. Ogikian1 , R. Da Silva2,3 , P.-M. François3 , Y. Matton3 , A. Rousseau2
Affiliations:
1ETAP-Lab, Département de Dermatologie, Vandoeuvre-lès-Nancy, France
2Ecole Polytechnique, Laboratoire de Physique des Plasmas, CNRS, Palaiseau, France
3Plasana Médical, Boulogne-Billancourt, France
Abstract: Ischemic ulcers are chronic wounds that occur due to reduced blood flow and are characterized by their inability to heal within an expected time frame. Cold atmospheric plasma (CAP) has emerged as a promising non-invasive therapy capable of enhancing wound healing. Plasana One® is a medical device manufactured by Plasana Medical, based on an argon plasma quadrijet. On contact with the ambient air, CAP creates reactive chemical species of oxygen and nitrogen such as nitric oxide, known to promote healing. The purpose of the study was to evaluate the pro-healing effects of Plasana One® on experimental ischemic skin wounds. The four jets of Argon-generated cold plasmas were applied under anesthesia 3 times per week during 0 (untreated), 20 or 120 seconds on and around 26 mm diameter induced ischemic skin wounds on the back of rats, until complete healing. Both treatment durations led to a significantly faster and more pronounced production of granulation tissue, followed by a more rapid decrease compared to untreated rats. No signs of maceration were observed throughout the study on wounds of cold plasma treated rats unlike untreated rats. Both treatment durations resulted in a significantly faster healing compared to untreated rats (68.0±5.3, 34.2±2.9, 32.4±1.9 and days for durations of 0, 20, 120 seconds respectively). Histological and immunohistochemical analyses of healed wounds showed that CAP treatments resulted in a more mature, thinner, well-organized, and differentiated neo-epidermis, as well as a more advanced stage of dermal scar tissue maturation, less inflammation, and greater neovascularization (number and size of newly formed blood vessels), with no difference between the two treatment durations. Hematological, blood biochemical and histological analyses of the main organs of cold plasma treated rats showed no significant difference compared to untreated rats.
