März 2022

The poster we presented at the Alzheimer’s Disease and Parkinson’s Disease conference is now available ; it’s all about our innovative in vitro and in vivo models of Alzheimer’s disease, which are based on the use of human A-Beta 1-42 oligomers. The poster focuses on the main results of the characterisation of the model in the aged mouse. This reproducible and translational model is a new tool for the evaluation of compounds targeting the early stages of Alzheimer’s disease. We are very

Dr. Ahmad Allouche (Head of In Vitro Biology at ETAP-Lab) is co-author of the article: “Neurodegeneration and neuroinflammation are linked, but independent of alpha-synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease” published in the journal Glia. Conducted in collaboration with Dr. @Manuel Buttini from Luxembourg (National Center of Pathology), this work shows that, in the early induction stages of the Parkinson's disease process, diffusible alpha-synuclein oligomers spreeding is responsible for neurodegeneration and neuroinflammation. This induces microglia activation, prior to