PRECLINICAL CRO SERVICES
SYNCROSOME
Dedicated lab for Cardiovascular diseases
SYNCROSOME is ETAP-Lab’s dedicated laboratory for cardiovascular research. Since its integration in 2023, it has reinforced our capabilities with specialized platforms in surgery and in vivo imaging, enhancing our ability to deliver high-quality, translational preclinical studies.
Our cardiovascular expertise covers a wide range of in vivo models addressing both right and left heart pathologies. These include models of pulmonary arterial hypertension (PAH), ischemia-reperfusion injury (IRI), as well as heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF). Each model is designed to reflect clinically relevant conditions and support the development of innovative therapeutic strategies.
Our models
Left Heart Disease Models
Heart Failure with preserved Ejection Fraction | HFpEF
Dahl SS rats (Hypertention & Fibrosis)
BTBR ob/ob mice (Obesity & Diabetes)
Heart Failure with reduced Ejection Fraction | HFrEF
Induced with Isoproterenol
Induced with Permanent ligation of Left Anterior Descending coronary artery (LAD)
Induced with Transient ligation of LAD
Acute Ischemia Reperfusion Injury model
Right Heart Disease Models
Pulmonary arterial hypertension | PAH
induced by Sugen/Hypoxia
induced by Monocrotaline
MAIN READOUTS
Morphological and functional parameters (Vevo F2) | Hemodynamic measurements (Millar probes) |Immuno-Histology analyses | Renal function evaluation | Blood analyses | Glycemia
Anatomopathology observation
Our platforms
Microsurgery
In vivo Imaging
Histology & Immunohistochemistry
Biological Assays