January 2018

New atopic dermatitis mouse model for in vivo efficacy studies Atopic dermatitis is a chronic allergic disease of the skin characterized by pruritus and eczematous skin lesions. It affects about 10 million people in the world, leading to a significant reduction in quality of life, and its incidence is continuously increasing in westernized countries. The pathogenesis of atopic dermatitis is unknown, but the disease seems to be correlated with specific immune and inflammatory mechanisms and keratinocytes, which are the main