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Published on the 16 December 2013

Structure- Activity Relationship Study and Function-Based Petidomimetic Design of Human Opiorphin with Improved Bioavailability Property and Unaltered Analgesic Activity

Human opiorphin inhibits enkephalin-inactivating ectopeptidases to produce analgesic and antidepressant-like effects in standard murine models via activation of µ and/or δ opioid pathways. It is an en…

Publications
Published on the 1 July 2013

Oral administration of d-limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans

AIMS: To further explore the anti-inflammatory properties of d-Limonene. MAIN METHODS: A rat model was used to compare evolution of TNBS (2,5,6-trinitrobenzene sulfonic acid)-induced colitis …

Publications
Published on the 28 June 2013

Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse

Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse. C57BL/6J mice orally exposed to 9% H. radicata (HR) are …

Publications
Published on the 1 June 2013

Effects of TLC-Ag dressings on skin inflammation

The TLC-Ag dressings, a combination of technology lipido-colloid and silver salts, are used to promote healing in wounds with risks or signs of local infection, thanks to the antimicrobial properties …

Publications
Published on the 1 January 2013

Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats

BACKGROUND: The purpose of the study was to evaluate the effects of krill oil (KO) on cognition and depression-like behaviour in rats. METHODS: Cognition was assessed using the Aversive Light Stimulus…

Publications
Published on the 1 May 2012

Effects of ID-alG™ on weight management and body fat mass in high-fat-fed rats

Seaweed extract of Ascophyllum nodosum, ID-alG™, was evaluated for its chronic effects on weight management in high-fat-fed Sprague-Dawley rats. ID-alG™ was orally administered daily during 9 weeks at…

Publications
Published on the 1 April 2012

Context-dependent modulation of hippocampal and cortical recruitment during remote spatial memory retrieval

According to systems consolidation, as hippocampal-dependent memories mature over time, they become additionally (or exclusively) dependent on extra-hippocampal structures. We assessed the recruitment…

Publications
Published on the 1 July 2011

Neurobehavioral and physiological effects of low doses of polubrominated diphenyl ether (PBDE)-99 in male adult rats

Polybrominated diphenyl ethers (PBDEs) are flame retardants. Because of their high lipophilicity and persistence, PBDEs bioaccumulate in all abiotic and biological matrices. The aim of this study was …

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