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Published on the 8 February 2025

POSTER: “Translational Relevance and Versatility of the Thromboembolic Stroke Model in Mice: Implications for Pharmacological and Safety Evaluations”

Dr Annelise LETOURNEUR, Director of Operations at STROK@LLIANCE and Neuroscience Study Director, presented the team's research* during the American Heart Association’s annual International Stroke Conf…

Posters
Published on the 8 January 2024

Improving Stroke Outcomes in Hyperglycemic Mice by Modulating tPA/NMDAR Signaling to Reduce Inflammation and Hemorrhages

The pharmacological intervention for ischemic stroke hinges on intravenous administration of the recombinant tissue-type plasminogen activator (rtPA, Alteplase/Actilyse®) either as a standalone treatm…

Publications
Published on the 21 December 2023

Dynamics of cerebral blood volume during and after middle cerebral artery occlusion in rats – Comparison between ultrafast ultrasound and dynamic susceptibility contrast-enhanced MRI measurements

Tomographic perfusion imaging techniques are integral to translational stroke research paradigms that advance our understanding of the disease. Functional ultrasound (fUS) is an emerging technique tha…

Publications
Published on the 17 May 2022

Preclinical models of cerebral haemorrhage

Haemorrhagic strokes account for 10-15% of all strokes. In 40% of patients, haemorrhagic strokes are fatal within one month, rising to 54% after 1 year. Haemorrhagic strokes have a devastating effect …

Technical notes
Published on the 15 November 2021

Post-acute delivery of α5-GABAA antagonist, S 44819, improves functional recovery in juvenile rats following stroke

Hypo-excitability was reported in the peri-infarct tissue following stroke, an effect counteracted by a blockage of α5-GABAA receptors in adult rodents. Our present study aims to evaluate the effect o…

Publications
Published on the 1 March 2021

Newsletter #7: From bench to bed side: how the new preclinical stroke models change the game.

Strokes are the second most common cause of mortality in the over-60s and the leading cause of acquired disability. There are currently only two approved treatments for the management of patients affe…

Technical notes
Published on the 3 September 2020

Early Ultrafast Ultrasound Imaging of Cerebral Perfusion correlates with Ischemic Stroke outcomes and responses to treatment in Mice

In the field of ischemic cerebral injury, precise characterization of neurovascular hemodynamic is required to select candidates for reperfusion treatments. It is thus admitted that advanced imaging-b…

Publications
Published on the 7 October 2019

Newsletter #6 – Modeling diversity in preclinical stroke

Taking clinical heterogeneity into account to increase the translational value of our preclinical models: the new STROK@LLIANCE research project Early in 2019, we announced the launch of a collabor…

Technical notes