Injecting sizecalibrated autologous blood clots induces embolic occlusion of the proximal MCA segment. This model produces cortical and subcortical lesions similar to those observed in mechanical ischemia models. Mortality, deficit severity, and responsiveness to the reference fibrinolytic treatment (Alteplase) can be modulated by adjusting the amount of thrombotic material used for the embolic event. This original and wellcharacterized model enables the evaluation of a wide range of therapeutic strategies, together with longterm monitoring of functional recovery.

ICH induced by collagenase injection Stereotaxic injection of collagenase rapidly disrupts the vascular endothelium, inducing a reproducible hemorrhage with the formation of an intracerebral hematoma, accompanied by an inflammatory response and clear neurological deficits. This ICH model provides a valuable translational tool for assessing the efficacy of your drug candidates on bleeding, neuroinflammation, and neuroprotection. Depending on your needs, it also offers the possibility to evaluate the risk of rebleeding or the effectiveness of antidotes across a panel of reference anticoagulants and fibrinolytics.

Validated model available in rats