Stereotaxic injection of collagenase rapidly disrupts the vascular endothelium, inducing a reproducible hemorrhage with the formation of an intracerebral hematoma, accompanied by an inflammatory response and clear neurological deficits. This ICH model provides a valuable translational tool for assessing the efficacy of your drug candidates on bleeding, neuroinflammation, and neuroprotection. Depending on your needs, it also offers the possibility to evaluate the risk of rebleeding or the effectiveness of antidotes across a panel of reference anticoagulants and fibrinolytics.
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ICH induced by autologous blood injection
Stereotaxic infusion of a predetermined volume of autologous blood into the striatum generates a reproducible hematoma, inducing increased intracranial pressure, brain toxicity, and an inflammatory response associated with clear neurological deficits. This model provides a reliable tool for evaluating the efficacy of your drug candidates on edema, inflammation, or neuroprotection, while eliminating potential biases linked to their effects on bleeding volume.
Stereotaxic infusion of a predetermined volume of autologous blood into the striatum generates a reproducible hematoma, inducing increased intracranial pressure, cerebral toxicity, and an inflammatory response associated with clear neurological deficits. This model is a reproducible tool for evaluating the efficacy of your molecules on edema, inflammation, or neuroprotection, eliminating potential biases related to their effect on bleeding volume.
Validated model available in rats.
