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Published on the 21 December 2023

Dynamics of cerebral blood volume during and after middle cerebral artery occlusion in rats – Comparison between ultrafast ultrasound and dynamic susceptibility contrast-enhanced MRI measurements

Tomographic perfusion imaging techniques are integral to translational stroke research paradigms that advance our understanding of the disease. Functional ultrasound (fUS) is an emerging technique tha…

Publications
Published on the 13 July 2023

A New Moisturiser Improves DNCB-induced Atopic Dermatitis-like Symptoms and Restores Skin Barrier Function in BALB/c Mice

Introduction Atopic dermatitis (AD) is a chronic, inflammatory skin disorder with eczematous and pruritic lesions. Topical moisturisers and either topical corticosteroids or calcineurin inhibitors …

Publications
Published on the 22 May 2022

The Anxiolytic-like Properties of a Tryptic Hydrolysate of Bovine αs1 Casein Containing α-Casozepine Rely on GABAA Receptor Benzodiazepine Binding Sites but Not the Vagus Nerve

Background A tryptic hydrolysate of bovine αs1-casein (CH) exerts anxiolytic-like properties in many species, including humans. This is mainly related to the presence of α-casozepine (α-CZP), which…

Publications
Published on the 17 May 2022

Preclinical models of cerebral haemorrhage

Haemorrhagic strokes account for 10-15% of all strokes. In 40% of patients, haemorrhagic strokes are fatal within one month, rising to 54% after 1 year. Haemorrhagic strokes have a devastating effect …

Technical notes
Published on the 25 February 2022

Antitumor Effect and Induced Immune Response Following Exposure of Hexaminolevulinate and Blue Light in Combination with Checkpoint Inhibitor in an Orthotopic Model of Rat Bladder Cancer

Previous studies have found that use of hexaminolevulinate (HAL) and blue light cystoscopy (BLC) during treatment of bladder cancer had a positive impact on overall survival after later cystectomy, in…

Publications
Published on the 15 November 2021

Post-acute delivery of α5-GABAA antagonist, S 44819, improves functional recovery in juvenile rats following stroke

Hypo-excitability was reported in the peri-infarct tissue following stroke, an effect counteracted by a blockage of α5-GABAA receptors in adult rodents. Our present study aims to evaluate the effect o…

Publications
Published on the 22 September 2021

Newsletter #11: World Alzheimer’s Day: review of the ETAP-Lab preclinical models

We'd like to take the opportunity, on World Alzheimer's Day, to revisit the models ETAP-Lab makes available to the scientific community for use in the search for new therapies to fight this disease. …

Technical notes
Published on the 14 September 2021

Newsletter #10 – New preclinical model of pruritus and update to our other atopic dermatitis models

Atopic dermatitis is a skin condition affecting 4% of the population worldwide. It affects all age groups, regardless of sex. Over the past 30 years, the number of diagnosed cases in industrialised co…

Technical notes