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Published on the 21 January 2021

Newsletter #8: The ETAP-Lab Psoriasis Model

The psoriasis model induced by the chronic application of imiquimod (IMI) proposed by ETAP-Lab reproducibly replicates the key markers of the pathology observed in humans: hyperproliferation of kerati…

Technical notes
Published on the 27 November 2020

New hope for Alzheimer’s disease: what’s combining therapeutic strategies all about?

Evidence from various studies indicates that Alzheimer’s Disease (AD) develops as a result of interaction between multiple complex and overlapping pathophysiological pathways, suggesting that a pharma…

Technical notes
Published on the 26 November 2020

Tau Clinical Trials – What can be learned from failure?

On the basis of the amyloid hypothesis of Alzheimer’s Disease (AD), most of the clinical trials conducted have concerned Aβ clearing therapy. Because of multiple failures in anti-amyloid clinical drug…

Technical notes
Published on the 26 November 2020

6 reasons to include tau oligomers in your R&D strategy for the treatment of Alzheimer’s Disease

As its name suggests, the microtubule-associated protein tau is known mainly for its role in stabilising the microtubules, thus contributing to maintenance of the axonal transport mechanisms essential…

Technical notes
Published on the 26 November 2020

Tau oligomers: a new tool for drug discovery in AD

One common pathological hallmark of neurodegenerative disease (ND) is the aggregation and accumulation of misfolding proteins, resulting in neuronal dysfunction and brain damage. A growing body of lit…

Technical notes
Published on the 3 September 2020

Early Ultrafast Ultrasound Imaging of Cerebral Perfusion correlates with Ischemic Stroke outcomes and responses to treatment in Mice

In the field of ischemic cerebral injury, precise characterization of neurovascular hemodynamic is required to select candidates for reperfusion treatments. It is thus admitted that advanced imaging-b…

Publications
Published on the 7 October 2019

Newsletter #6 – Modeling diversity in preclinical stroke

Taking clinical heterogeneity into account to increase the translational value of our preclinical models: the new STROK@LLIANCE research project Early in 2019, we announced the launch of a collabor…

Technical notes
Published on the 18 September 2019

Model of atopic dermatitis in mice: feedback – Newsletter #6

In January 2018, we announced the validation of a new model of atopic dermatitis in mice. Now that we have 18 months’ experience of using it, here’s our feedback. Back in January 2018, we…

Technical notes