The new tau oligomers produced by ETAP-Lab show reproducible and dose-dependent toxicity on rodent primary neuron cultures.
Promising and repeatedly replicated data show that tau oligomers exhibit dose-dependent toxicity that is not observed with equivalent monomer concentrations. At high concentrations, the oligomers completely destabilise the neurons, leading to a rapid mortality rate of 100%.
Now that the main technical obstacles have been overcome, a validated model for pharmacological screening should be ready soon. The next step is to evaluate some reference compounds. The first BDNF results are expected within a couple of weeks.
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